Anti-COBRA1 antibody (Full Length) [F7E4] (STJA0003598) STJA0003598-100 上海玉博生物科技有限公司

Anti-COBRA1 antibody (Full Length) [F7E4] (STJA0003598)

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产品名称：Anti-COBRA1 antibody (Full Length) [F7E4] (STJA0003598)
产品型号：STJA0003598-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-COBRA1 antibody (Full Length) [F7E4] (STJA0003598)

产品描述

Host:	Mouse
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-COBRA1 (Full Length) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	F7E4
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification:	This antibody was protein g purified culture from supernatant.
Dilution Range:	WB 1:1000 IHC ICC IP
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NELFB
Gene ID:	25920
Uniprot ID:	NELFB_HUMAN
Immunogen Region:	Full Length
Immunogen:	Recombinant full length human COBRA1 purification from E. coli.

Tissue Specificity	Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
Function	Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. Essential for early embryogenesis.plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes. Plays a key role in establishing the responsiveness of stem cells to developmental cues.facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules. Supports the transcription of genes involved in energy metabolism in cardiomyocytes.facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes. (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1.
Protein Name	Negative Elongation Factor B Nelf-B Cofactor Of Brca1
Database Links	Reactome: R-HSA-112382 Reactome: R-HSA-113418 Reactome: R-HSA-167152 Reactome: R-HSA-167158 Reactome: R-HSA-167200 Reactome: R-HSA-167238 Reactome: R-HSA-167242 Reactome: R-HSA-167243 Reactome: R-HSA-167246 Reactome: R-HSA-167287 Reactome: R-HSA-167290 Reactome: R-HSA-674695 Reactome: R-HSA-6796648 Reactome: R-HSA-75955 Reactome: R-HSA-9603505
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Negative Elongation Factor B antibody Anti-Nelf-B antibody Anti-Cofactor Of Brca1 antibody Anti-NELFB antibody Anti-COBRA1 antibody Anti-KIAA1182 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-COBRA1 antibody (Full Length) [F7E4] (STJA0003598)