Human USP8 (Ubiquitin Specific Peptidase 8) Sandwich ELISA Kit Ready-To-Use (STJE0019344) STJE0019344 上海玉博生物科技有限公司

Human USP8 (Ubiquitin Specific Peptidase 8) Sandwich ELISA Kit Ready-To-Use (STJE0019344)

如果您对该产品感兴趣的话，可以
产品名称：Human USP8 (Ubiquitin Specific Peptidase 8) Sandwich ELISA Kit Ready-To-Use (STJE0019344)
产品型号：STJE0019344
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human USP8 (Ubiquitin Specific Peptidase 8) Sandwich ELISA Kit Ready-To-Use (STJE0019344)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.101ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This USP8 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	USP8
Gene ID:	9101
Uniprot ID:	UBP8_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Phosphorylation of Ser-718 is essential for interaction with YWHAE and for cytosol localization. Undergoes dephosphorylation at Ser-718 in the M phase. Tyrosine-phosphorylated in its N-terminal half in an EGFR-dependent manner. Ubiquitinated. Inactive form is mostly monoubiquitinated, but polyubiquitination happens too. Ubiquitination is increased in EGF-stimulated cells. Ubiquitination of active form is undetectable, suggesting a possibility that USP8 deubiquitinates itself, thereby regulating its own function.
Function	Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation.
Protein Name	Ubiquitin Carboxyl-Terminal Hydrolase 8 Deubiquitinating Enzyme 8 Ubiquitin Isopeptidase Y Hubpy Ubiquitin Thioesterase 8 Ubiquitin-Specific-Processing Protease 8
Database Links	Reactome: R-HSA-1358803 Reactome: R-HSA-4641263 Reactome: R-HSA-5689880 Reactome: R-HSA-6807004
Cellular Localisation	Cytoplasm Nucleus Endosome Membrane Peripheral Membrane Protein Cell Membrane
Alternative ELISA Names	Ubiquitin Carboxyl-Terminal Hydrolase 8 ELISA kit Deubiquitinating Enzyme 8 ELISA kit Ubiquitin Isopeptidase Y ELISA kit Hubpy ELISA kit Ubiquitin Thioesterase 8 ELISA kit Ubiquitin-Specific-Processing Protease 8 ELISA kit USP8 ELISA kit KIAA0055 ELISA kit UBPY ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Human USP8 (Ubiquitin Specific Peptidase 8) Sandwich ELISA Kit Ready-To-Use (STJE0019344)