Human VDAC1 (Voltage Dependent Anion Channel Protein 1) Sandwich ELISA Kit (STJE0012992) STJE0012992 上海玉博生物科技有限公司

Human VDAC1 (Voltage Dependent Anion Channel Protein 1) Sandwich ELISA Kit (STJE0012992)

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产品名称：Human VDAC1 (Voltage Dependent Anion Channel Protein 1) Sandwich ELISA Kit (STJE0012992)
产品型号：STJE0012992
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human VDAC1 (Voltage Dependent Anion Channel Protein 1) Sandwich ELISA Kit (STJE0012992)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	13.8pg/mL
Detection Limit:	31.2-2000pg/mL
Short Description:	This VDAC1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	VDAC1
Gene ID:	7416
Uniprot ID:	VDAC1_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Expressed in erythrocytes (at protein level). Expressed in heart, liver and skeletal muscle.
Post Translational Modifications	Phosphorylation at Ser-193 by NEK1 promotes the open conformational state preventing excessive mitochondrial membrane permeability and subsequent apoptotic cell death after injury. Phosphorylation by the AKT-GSK3B axis stabilizes the protein probably by preventing ubiquitin-mediated proteasomal degradation. Ubiquitinated. Undergoes monoubiquitination and polyubiquitination by PRKN.monoubiquitination at Lys-274 inhibits apoptosis, whereas polyubiquitination leads to its degradation and promotes mitophagy. Deubiquitinated by USP30.
Function	Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules.in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis.polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. May mediate ATP export from cells.
Protein Name	Voltage-Dependent Anion-Selective Channel Protein 1 Vdac-1 Hvdac1 Outer Mitochondrial Membrane Protein Porin 1 Plasmalemmal Porin Porin 31hl Porin 31hm
Database Links	Reactome: R-HSA-1268020 Reactome: R-HSA-5205685 Reactome: R-HSA-5689880 Reactome: R-HSA-70268 Reactome: R-HSA-8949215
Cellular Localisation	Mitochondrion Outer Membrane Multi-Pass Membrane Protein Cell Membrane Membrane Raft
Alternative ELISA Names	Voltage-Dependent Anion-Selective Channel Protein 1 ELISA kit Vdac-1 ELISA kit Hvdac1 ELISA kit Outer Mitochondrial Membrane Protein Porin 1 ELISA kit Plasmalemmal Porin ELISA kit Porin 31hl ELISA kit Porin 31hm ELISA kit VDAC1 ELISA kit VDAC ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human VDAC1 (Voltage Dependent Anion Channel Protein 1) Sandwich ELISA Kit (STJE0012992)