Anti-COL25A1 antibody (NC2-2 region) (STJA0005755) STJA0005755-100 上海玉博生物科技有限公司

Anti-COL25A1 antibody (NC2-2 region) (STJA0005755)

简单介绍

Anti-COL25A1 antibody (NC2-2 region) (STJA0005755)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CLAC-P (NC2-2 region) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS + 0.02% NaN3
Purification:	Antigen Affinity Purified
Dilution Range:	WB 1:500-1:1000 IHC ICC IP
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	COL25A1
Gene ID:	84570
Uniprot ID:	COPA1_HUMAN
Immunogen Region:	NC2-2 region
Specificity:	Reacts with the NC2-2 region of human and mouse CLAC-P. Detects bands of 50, 70 and 100 kDa in SPs of AD brain, but not in diffuse plaques of non-demented aged individuals, diffuse deposits in sub-cortical structures and cerebellum in AD nor in cereb
Immunogen:	Synthetic peptide corresponding to amino acids from the NC2-2 region of human CLAC-P

Post Translational Modifications	Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. Glycosylated. Hydroxylated on 11% of proline residues and 49% of lysine residues.
Function	Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Protein Name	Collagen Alpha-1(Xxv Chain Alzheimer Disease Amyloid-Associated Protein Amy Clac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque Component Clac
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1650814 Reactome: R-HSA-8948216
Cellular Localisation	Membrane Single-Pass Type Ii Membrane Protein After Proteolytic Cleavage Clac Is Secreted
Alternative Antibody Names	Anti-Collagen Alpha-1(Xxv Chain antibody Anti-Alzheimer Disease Amyloid-Associated Protein antibody Anti-Amy antibody Anti-Clac-P Cleaved Into - Collagen-Like Alzheimer Amyloid Plaque Component antibody Anti-Clac antibody Anti-COL25A1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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