Anti-COL4A5 antibody (1462-1691) (STJ111851) STJ111851 上海玉博生物科技有限公司

Anti-COL4A5 antibody (1462-1691) (STJ111851)

简单介绍

Anti-COL4A5 antibody (1462-1691) (STJ111851)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-COL4A5 (1462-1691) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	COL4A5
Gene ID:	1287
Uniprot ID:	CO4A5_HUMAN
Immunogen Region:	1462-1691
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1462-1691 of human COL4A5 (NP_203699.1).
Immunogen Sequence:	SSVAHGFLITRHSQTTDAPQ CPQGTLQVYEGFSLLYVQGN KRAHGQDLGTAGSCLRRFST MPFMFCNINNVCNFASRNDY SYWLSTPEPMPMSMQPLKGQ SIQPFISRCAVCEAPAVVIA VHSQTIQIPHCPQGWDSLWI GYSFMMHTSAGAEGSGQALA SPGSCLEEFRSAPFIECHGR GTCNYYANSYSFWLATVDVS DMFSKPQSETLKAGDLRTRI SRCQVCMKRT

Tissue Specificity	Isoform 2 is found in kidney.
Post Translational Modifications	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens. The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.
Function	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
Protein Name	Collagen Alpha-5(Iv Chain
Database Links	Reactome: R-HSA-1442490 Reactome: R-HSA-1474244 Reactome: R-HSA-1650814 Reactome: R-HSA-186797 Reactome: R-HSA-2022090 Reactome: R-HSA-216083 Reactome: R-HSA-2214320 Reactome: R-HSA-2243919 Reactome: R-HSA-3000157 Reactome: R-HSA-3000171 Reactome: R-HSA-3000178 Reactome: R-HSA-419037 Reactome: R-HSA-8948216 Reactome: R-HSA-9010553
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix Basement Membrane
Alternative Antibody Names	Anti-Collagen Alpha-5(Iv Chain antibody Anti-COL4A5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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