Human VEGFA (VEGFA) Sandwich ELISA Kit (STJE0000013) STJE0000013-96 上海玉博生物科技有限公司

Human VEGFA (VEGFA) Sandwich ELISA Kit (STJE0000013)

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产品名称：Human VEGFA (VEGFA) Sandwich ELISA Kit (STJE0000013)
产品型号：STJE0000013-96
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human VEGFA (VEGFA) Sandwich ELISA Kit (STJE0000013)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	7.8 pg/mL
Detection Limit:	312-2000 pg/mL
Short Description:	This VEGFA Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Conjugation:	Biotin
Storage Instruction:	Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time:	4 hours
Detection:	Colorimetric

Gene Symbol:	VEGFA
Gene ID:	7422
Uniprot ID:	VEGFA_HUMAN
Sample Type:	serum, plasma, cell culture supernates

Tissue Specificity	Higher expression in pituitary tumors than the pituitary gland. Isoform VEGF189: Widely expressed. Isoform VEGF165: Widely expressed. Isoform VEGF121: Widely expressed. Isoform VEGF206: Not widely expressed. Isoform VEGF145: Not widely expressed.
Post Translational Modifications	Vascular endothelial growth factor A, long form: Produced by use of an alternative upstream CUG codon and post-translationally processed into the N-terminal N-VEGF form and the C-terminal secreted VEGFA form.
Function	N-VEGF: Participates in the induction of key genes involved in the response to hypoxia and in the induction of angiogenesis such as HIF1A. Involved in protecting cells from hypoxia-mediated cell death. VEGFA: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. Binds to the NRP1/neuropilin-1 receptor. Binding to NRP1 initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor. Isoform VEGF165B: Binds to the KDR receptor but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Protein Name	Vascular Endothelial Growth Factor A - Long Form L-Vegf Vascular Permeability Factor Vpf Cleaved Into - N-Vegf - Vegfa
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-1234158 Reactome: R-HSA-194138 Reactome: R-HSA-194313 Reactome: R-HSA-195399 Reactome: R-HSA-4420097 P15692-4 Reactome: R-HSA-5218921 P15692-4 Reactome: R-HSA-6785807 Reactome: R-HSA-8866910 Reactome: R-HSA-9679191 P15692-4
Cellular Localisation	N-Vegf: Cytoplasm Nucleus Cytoplasmic In Normoxic Conditions And Localizes To The Nucleus Under Hypoxic Conditions Vegfa: Secreted Isoform L-Vegf189: Endoplasmic Reticulum Golgi Apparatus Secreted Extracellular Space Extracellular Matrix Isoform Vegf121: Secreted Isoform Vegf165: Secreted Isoform Vegf189: Secreted Cell-Associated After Secretion And Is Bound Avidly By Heparin And The Extracellular Matrix Although It May Be Released As A Soluble Form By Heparin Heparinase Or Plasmin
Alternative ELISA Names	Vascular Endothelial Growth Factor A - Long Form ELISA kit L-Vegf ELISA kit Vascular Permeability Factor ELISA kit Vpf Cleaved Into - N-Vegf - Vegfa ELISA kit VEGFA ELISA kit VEGF ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Human VEGFA (VEGFA) Sandwich ELISA Kit (STJE0000013)