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Human VISA (Virus Induced Signaling Adapter) Sandwich ELISA Kit (STJE0013050)
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Human VISA (Virus Induced Signaling Adapter) Sandwich ELISA Kit (STJE0013050)
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Human VISA (Virus Induced Signaling Adapter) Sandwich ELISA Kit (STJE0013050)
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产品名称:
Human VISA (Virus Induced Signaling Adapter) Sandwich ELISA Kit (STJE0013050)
产品型号:
STJE0013050
产品展商:
ST john's laboratory
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简单介绍
Human VISA (Virus Induced Signaling Adapter) Sandwich ELISA Kit (STJE0013050)
产品描述
Applications:
ELISA
Reactivity:
Human
Note:
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:
0.068ng/mL
Detection Limit:
0.156-10ng/mL
Short Description:
This VISA Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction:
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:
4.5 hrs
Gene Symbol:
MAVS
Gene ID:
57506
Uniprot ID:
MAVS_HUMAN
Sample Type:
tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.
Post Translational Modifications
Following activation, phosphorylated by TBK1 at Ser-442 in the pLxIS motif. The phosphorylated pLxIS motif constitutes an IRF3-binding motif, leading to recruitment of the transcription factor IRF3 to induce type-I interferons and other cytokines. Ubiquitinated. Undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH.ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation. Ubiquitinated by RNF125, leading to its degradation by the proteasome. Undergoes 'Lys-48'-linked ubiquitination catalyzed by SMURF1. Ubiquitinated via 'Lys-63'-linked ubiquitination at Lys-10, Lys-311 and Lys-461 by TRIM31, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Undergoes 'Lys-63'-linked ubiquitination leading to enhanced interaction between MAVS and TRAF2. Undergoes 'Lys-27'-linked ubiquitination by TRIM21 leading to enhanced interaction between MAVS and TBK1. Proteolytically cleaved by apoptotic caspases during apoptosis, leading to its inactivation. Cleavage by CASP3 during virus-induced apoptosis inactivates it, preventing cytokine overproduction. (Microbial infection) Cleaved and degraded by hepatitis A virus (HAV) protein 3ABC allowing the virus to disrupt the activation of host IRF3 through the MDA5 pathway. (Microbial infection) Cleaved by the protease 2A of coxsackievirus B3, poliovirus and enterovirus 71 allowing the virus to disrupt the host type I interferon production. (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I production. (Microbial infection) Cleaved by HCV protease NS3/4A, thereby preventing the establishment of an antiviral state. (Microbial infection) UFMylated by ULF1 in association with Epstein-Barr virus BILF1.leading to MAVS routing to the lysosome.
Function
Adapter required for innate immune defense against viruses. Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria.
Protein Name
Mitochondrial Antiviral-Signaling Protein
Mavs
Card Adapter Inducing Interferon Beta
Cardif
Interferon Beta Promoter Stimulator Protein 1
Ips-1
Putative Nf-Kappa-B-Activating Protein 031n
Virus-Induced-Signaling Adapter
Visa
Database Links
Reactome: R-HSA-168928
Reactome: R-HSA-5689896
Reactome: R-HSA-918233
Reactome: R-HSA-933541
Reactome: R-HSA-933542
Reactome: R-HSA-933543
Reactome: R-HSA-936440
Reactome: R-HSA-9692916
Reactome: R-HSA-9705671
Cellular Localisation
Mitochondrion Outer Membrane
Single-Pass Membrane Protein
Mitochondrion
Peroxisome
Alternative ELISA Names
Mitochondrial Antiviral-Signaling Protein ELISA kit
Mavs ELISA kit
Card Adapter Inducing Interferon Beta ELISA kit
Cardif ELISA kit
Interferon Beta Promoter Stimulator Protein 1 ELISA kit
Ips-1 ELISA kit
Putative Nf-Kappa-B-Activating Protein 031n ELISA kit
Virus-Induced-Signaling Adapter ELISA kit
Visa ELISA kit
MAVS ELISA kit
IPS1 ELISA kit
KIAA1271 ELISA kit
VISA ELISA kit
output
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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