Human VRK1 (Vaccinia Related Kinase 1) Sandwich ELISA Kit Ready-To-Use (STJE0019453) STJE0019453 上海玉博生物科技有限公司

Human VRK1 (Vaccinia Related Kinase 1) Sandwich ELISA Kit Ready-To-Use (STJE0019453)

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产品名称：Human VRK1 (Vaccinia Related Kinase 1) Sandwich ELISA Kit Ready-To-Use (STJE0019453)
产品型号：STJE0019453
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Human VRK1 (Vaccinia Related Kinase 1) Sandwich ELISA Kit Ready-To-Use (STJE0019453)

产品描述

Applications:	ELISA
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.062ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This VRK1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	VRK1
Gene ID:	7443
Uniprot ID:	VRK1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma or other biological fluids.

Tissue Specificity	Widely expressed. Highly expressed in fetal liver, testis and thymus.
Post Translational Modifications	Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53. Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis.
Function	Serine/threonine kinase involved in cell cycle, nuclear condensation and transcription regulation. Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Protein Name	Serine/Threonine-Protein Kinase Vrk1 Vaccinia-Related Kinase 1
Database Links	Reactome: R-HSA-2980766 Reactome: R-HSA-2995383
Cellular Localisation	Nucleus Cytoplasm Dispersed Throughout The Cell But Not Located On Mitotic Spindle Or Chromatids During Mitosis
Alternative ELISA Names	Serine/Threonine-Protein Kinase Vrk1 ELISA kit Vaccinia-Related Kinase 1 ELISA kit VRK1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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