Anti-COMP antibody (50-150) [S4782RM] (STJ11104782) STJ11104782 上海玉博生物科技有限公司

Anti-COMP antibody (50-150) [S4782RM] (STJ11104782)

简单介绍

Anti-COMP antibody (50-150) [S4782RM] (STJ11104782)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Cartilage Oligomeric Matrix Protein (50-150) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S4782RM
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:1000-1:5000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	COMP
Gene ID:	1311
Uniprot ID:	COMP_HUMAN
Immunogen Region:	50-150
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 50-150 of human COMP (NP_000086.2).
Immunogen Sequence:	ELLRQQVREITFLKNTVMEC DACGMQQSVRTGLPSVRPLL HCAPGFCFPGVACIQTESGA RCGPCPAGFTGNGSHCTDVN ECNAHPCFPRVRCINTSPGF R

Tissue Specificity	Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.
Function	Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
Protein Name	Cartilage Oligomeric Matrix Protein Comp Thrombospondin-5 Tsp5
Database Links	Reactome: R-HSA-216083 Reactome: R-HSA-3000178
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Cartilage Oligomeric Matrix Protein antibody Anti-Comp antibody Anti-Thrombospondin-5 antibody Anti-Tsp5 antibody Anti-COMP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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