Anti-Complement C4A antibody (940-1237) [S2MR] (STJ11103522) STJ11103522 上海玉博生物科技有限公司

Anti-Complement C4A antibody (940-1237) [S2MR] (STJ11103522)

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产品名称：Anti-Complement C4A antibody (940-1237) [S2MR] (STJ11103522)
产品型号：STJ11103522
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Complement C4A antibody (940-1237) [S2MR] (STJ11103522)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Complement C4A (940-1237) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	S2MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	C4A
Gene ID:	720/721
Uniprot ID:	CO4A_HUMAN
Immunogen Region:	940-1237
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 940-1237 of human Complement C4A (P0C0L4).
Immunogen Sequence:	HREELVYELNPLDHRGRTLE IPGNSDPNMIPDGDFNSYVR VTASDPLDTLGSEGALSPGG VASLLRLPRGCGEQTMIYLA PTLAASRYLDKTEQWSTLPP ETKDHAVDLIQKGYMRIQQF RKADGSYAAWLSRDSSTWLT AFVLKVLSLAQEQVGGSPEK LQETSNWLLSQQQADGSFQD PCPVLDRSMQGGLVGNDETV ALTAFVTIALHHGLAVFQDE GAEPLKQRVEASISKANSF

Tissue Specificity	Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland, and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response.
Post Translational Modifications	Prior to secretion, the single-chain precursor is enzymatically cleaved to yield non-identical chains alpha, beta and gamma. During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase. The proteolytic cleavages often are incomplete so that many structural forms can be found in plasma. N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Function	Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Protein Name	Complement C4-A Acidic Complement C4 C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 2 Cleaved Into - Complement C4 Beta Chain - Complement C4-A Alpha Chain - C4a Anaphylatoxin - C4b-A - C4d-A - Complement C4 Gamma Chain
Database Links	Reactome: R-HSA-166663 Reactome: R-HSA-174577 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-977606
Cellular Localisation	Secreted Synapse Cell Projection Axon Dendrite
Alternative Antibody Names	Anti-Complement C4-A antibody Anti-Acidic Complement C4 antibody Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 2 Cleaved Into - Complement C4 Beta Chain - Complement C4-A Alpha Chain - C4a Anaphylatoxin - C4b-A - C4d-A - Complement C4 Gamma Chain antibody Anti-C4A antibody Anti-CO4 antibody Anti-CPAMD2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Complement C4A antibody (940-1237) [S2MR] (STJ11103522)