Mouse SIRT3 (Sirtuin 3) Sandwich ELISA Kit (STJE0012175) STJE0012175 上海玉博生物科技有限公司

Mouse SIRT3 (Sirtuin 3) Sandwich ELISA Kit (STJE0012175)

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产品名称：Mouse SIRT3 (Sirtuin 3) Sandwich ELISA Kit (STJE0012175)
产品型号：STJE0012175
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Mouse SIRT3 (Sirtuin 3) Sandwich ELISA Kit (STJE0012175)

产品描述

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.055ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This SIRT3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Sirt3
Gene ID:	64384
Uniprot ID:	SIR3_MOUSE
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Strongly expressed in liver and kidney. Expressed in skeletal muscles (at protein level). Weakly expressed in lung.
Post Translational Modifications
Function	NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation. Regulates hepatic lipogenesis. Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately downregulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance.
Protein Name	Nad-Dependent Protein Deacetylase Sirtuin-3 Regulatory Protein Sir2 Homolog 3 Sir2-Like Protein 3 Msir2l3
Database Links	Reactome: R-MMU-2151201 Reactome: -MMU-9617629
Cellular Localisation	Isoform L: Mitochondrion Matrix Isoform S: Cytoplasm
Alternative ELISA Names	Nad-Dependent Protein Deacetylase Sirtuin-3 ELISA kit Regulatory Protein Sir2 Homolog 3 ELISA kit Sir2-Like Protein 3 ELISA kit Msir2l3 ELISA kit Sirt3 ELISA kit Sir2l3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Mouse SIRT3 (Sirtuin 3) Sandwich ELISA Kit (STJE0012175)