Anti-ESR1 antibody (STJ197393) STJ197393 上海玉博生物科技有限公司

Anti-ESR1 antibody (STJ197393)

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产品名称：Anti-ESR1 antibody (STJ197393)
产品型号：STJ197393
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ESR1 antibody (STJ197393)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Estrogen receptor is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ESR1
Gene ID:	2099
Uniprot ID:	ESR1_HUMAN
Specificity:	The antibody detects endogenous Estrogen Receptor Alpha protein
Immunogen:	Recombinant Protein of Estrogen Receptor Alpha

Post Translational Modifications	Phosphorylated by cyclin A/CDK2 and CK1. Phosphorylation probably enhances transcriptional activity. Self-association induces phosphorylation. Dephosphorylation at Ser-118 by PPP5C inhibits its transactivation activity. Phosphorylated by LMTK3 in vitro. Glycosylated.contains N-acetylglucosamine, probably O-linked. Ubiquitinated.regulated by LATS1 via DCAF1 it leads to ESR1 proteasomal degradation. Deubiquitinated by OTUB1. Dimethylated by PRMT1 at Arg-260. The methylation may favor cytoplasmic localization. Demethylated by JMJD6 at Arg-260. Palmitoylated (isoform 3). Not biotinylated (isoform 3). Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation, but not for signaling mediated by the nuclear hormone receptor.
Function	Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements.the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3: Involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Binds to ERE and inhibits isoform 1.
Protein Name	Estrogen Receptor Er Er-Alpha Estradiol Receptor Nuclear Receptor Subfamily 3 Group A Member 1
Database Links	Reactome: R-HSA-1251985 Reactome: R-HSA-1257604 Reactome: R-HSA-2219530 Reactome: R-HSA-383280 Reactome: R-HSA-4090294 Reactome: R-HSA-5689896 Reactome: R-HSA-6811558 Reactome: R-HSA-8866910 Reactome: R-HSA-8931987 Reactome: R-HSA-8939211 Reactome: R-HSA-8939256 Reactome: R-HSA-8939902 Reactome: R-HSA-9009391 Reactome: R-HSA-9018519
Cellular Localisation	Isoform 1: Nucleus Cytoplasm Cell Membrane Peripheral Membrane Protein Cytoplasmic Side A Minor Fraction Is Associated With The Inner Membrane Isoform 3: Nucleus Single-Pass Type I Membrane Protein Associated With The Inner Membrane Via Palmitoylation (Probable) At Least A Subset Exists As A Transmembrane Protein With A N-Terminal Extracellular Domain Nucleus Golgi Apparatus Colocalizes With Zdhhc7 And Zdhhc21 In The Golgi Apparatus Where Most Probably Palmitoylation Occurs Associated With The Plasma Membrane When Palmitoylated
Alternative Antibody Names	Anti-Estrogen Receptor antibody Anti-Er antibody Anti-Er-Alpha antibody Anti-Estradiol Receptor antibody Anti-Nuclear Receptor Subfamily 3 Group A Member 1 antibody Anti-ESR1 antibody Anti-ESR antibody Anti-NR3A1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ESR1 antibody (STJ197393)