Anti-ESRRA antibody (1-76) (STJ23577) STJ23577 上海玉博生物科技有限公司

Anti-ESRRA antibody (1-76) (STJ23577)

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产品名称：Anti-ESRRA antibody (1-76) (STJ23577)
产品型号：STJ23577
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ESRRA antibody (1-76) (STJ23577)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ESRRA (1-76) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ESRRA
Gene ID:	2101
Uniprot ID:	ERR1_HUMAN
Immunogen Region:	1-76
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-76 of human ESRRA (NP_004442.3).
Immunogen Sequence:	MSSQVVGIEPLYIKAEPASP DSPKGSSETETEPPVALAPG PAPTRCLPGHKEEEDGEGAG PGEQGGGKLVLSSLPK

Post Translational Modifications	Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity. Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding. Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity.deacetylation involves SIRT1 and HDAC8 and increases DNA-binding.
Function	Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle.
Protein Name	Steroid Hormone Receptor Err1 Estrogen Receptor-Like 1 Estrogen-Related Receptor Alpha Err-Alpha Nuclear Receptor Subfamily 3 Group B Member 1
Database Links	Reactome: R-HSA-1989781 Reactome: R-HSA-2151201 Reactome: R-HSA-383280 Reactome: R-HSA-8939902
Cellular Localisation	Nucleus Cytoplasm Co-Localizes To The Cytoplasm Only In Presence Of Mapk15
Alternative Antibody Names	Anti-Steroid Hormone Receptor Err1 antibody Anti-Estrogen Receptor-Like 1 antibody Anti-Estrogen-Related Receptor Alpha antibody Anti-Err-Alpha antibody Anti-Nuclear Receptor Subfamily 3 Group B Member 1 antibody Anti-ESRRA antibody Anti-ERR1 antibody Anti-ESRL1 antibody Anti-NR3B1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-ESRRA antibody (1-76) (STJ23577)