Anti-ESRRB antibody (300-400) (STJ115912) STJ115912 上海玉博生物科技有限公司

Anti-ESRRB antibody (300-400) (STJ115912)

如果您对该产品感兴趣的话，可以
产品名称：Anti-ESRRB antibody (300-400) (STJ115912)
产品型号：STJ115912
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ESRRB antibody (300-400) (STJ115912)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ESRRB (300-400) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ESRRB
Gene ID:	2103
Uniprot ID:	ERR2_HUMAN
Immunogen Region:	300-400
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ESRRB (NP_004443.3).
Immunogen Sequence:	VYAEDYIMDEEHSRLAGLLE LYRAILQLVRRYKKLKVEKE EFVTLKALALANSDSMYIED LEAVQKLQDLLHEALQDYEL SQRHEEPWRTGKLLLTLPLL R

Post Translational Modifications	Acetylated by PCAF/KAT2 (in vitro).
Function	Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Plays a role as transcription factor activator of GATA6, NR0B1, POU5F1 and PERM1. Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity. During mitosis remains bound to a subset of interphase target genes, including pluripotency regulators, through the canonical ESRRB recognition (ERRE) sequence, leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2, POU5F1, KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism, in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation. Isoform 1: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Positively regulates ESR1 transcriptional activity upon E2 stimulation.
Protein Name	Steroid Hormone Receptor Err2 Err Beta-2 Estrogen Receptor-Like 2 Estrogen-Related Receptor Beta Err-Beta Nuclear Receptor Subfamily 3 Group B Member 2
Database Links	Reactome: R-HSA-383280
Cellular Localisation	Nucleus Cytoplasm Chromosome
Alternative Antibody Names	Anti-Steroid Hormone Receptor Err2 antibody Anti-Err Beta-2 antibody Anti-Estrogen Receptor-Like 2 antibody Anti-Estrogen-Related Receptor Beta antibody Anti-Err-Beta antibody Anti-Nuclear Receptor Subfamily 3 Group B Member 2 antibody Anti-ESRRB antibody Anti-ERRB2 antibody Anti-ESRL2 antibody Anti-NR3B2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-ESRRB antibody (300-400) (STJ115912)