Mouse SOCS1 (Suppressors Of Cytokine Signaling 1) Sandwich ELISA Kit Ready-To-Use (STJE0018644) STJE0018644 上海玉博生物科技有限公司

Mouse SOCS1 (Suppressors Of Cytokine Signaling 1) Sandwich ELISA Kit Ready-To-Use (STJE0018644)

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产品名称：Mouse SOCS1 (Suppressors Of Cytokine Signaling 1) Sandwich ELISA Kit Ready-To-Use (STJE0018644)
产品型号：STJE0018644
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Mouse SOCS1 (Suppressors Of Cytokine Signaling 1) Sandwich ELISA Kit Ready-To-Use (STJE0018644)

产品描述

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.14ng/mL
Detection Limit:	0.312-20ng/mL
Short Description:	This SOCS1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Socs1
Gene ID:	12703
Uniprot ID:	SOCS1_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	High expression in thymus. Lower expression in lung and spleen. Expressed in both Th1 and Th2 cells.
Post Translational Modifications
Function	Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name	Suppressor Of Cytokine Signaling 1 Socs-1 Jak-Binding Protein Jab Stat-Induced Stat Inhibitor 1 Ssi-1
Database Links	Reactome: R-MMU-6785807 Reactome: -MMU-877300 Reactome: -MMU-877312 Reactome: -MMU-909733 Reactome: -MMU-9705462 Reactome: -MMU-983168
Cellular Localisation	Nucleus Cytoplasmic Vesicle Detected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3
Alternative ELISA Names	Suppressor Of Cytokine Signaling 1 ELISA kit Socs-1 ELISA kit Jak-Binding Protein ELISA kit Jab ELISA kit Stat-Induced Stat Inhibitor 1 ELISA kit Ssi-1 ELISA kit Socs1 ELISA kit Cish1 ELISA kit Ssi1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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