Anti-ETF1 antibody (278-437) (STJ27716) STJ27716 上海玉博生物科技有限公司

Anti-ETF1 antibody (278-437) (STJ27716)

如果您对该产品感兴趣的话，可以
产品名称：Anti-ETF1 antibody (278-437) (STJ27716)
产品型号：STJ27716
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-ETF1 antibody (278-437) (STJ27716)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-ETF1 (278-437) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:200-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ETF1
Gene ID:	2107
Uniprot ID:	ERF1_HUMAN
Immunogen Region:	278-437
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 278-437 of human ETF1 (NP_004721.1).
Immunogen Sequence:	VKFIQEKKLIGRYFDEISQD TGKYCFGVEDTLKALEMGAV EILIVYENLDIMRYVLHCQG TEEEKILYLTPEQEKDKSHF TDKETGQEHELIESMPLLEW FANNYKKFGATLEIVTDKSQ EGSQFVKGFGGIGGILRYRV DFQGMEYQGGDDEFFDLDDY

Post Translational Modifications	Methylated at Gln-185 by N6AMT1. Hydroxylation at Lys-63 by JMJD4 promotes its translational termination efficiency. Ubiquitinated via 'Lys-6'-linked polyubiquitin chains by RNF14 and RNF25 in response to ribosome collisions (ribosome stalling), leading to its degradation by the proteasome and rescue of stalled ribosomes.
Function	Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes.
Protein Name	Eukaryotic Peptide Chain Release Factor Subunit 1 Eukaryotic Release Factor 1 Erf1 Protein Cl1 Tb3-1
Database Links	Reactome: R-HSA-72764 Reactome: R-HSA-9010553 Reactome: R-HSA-975956 Reactome: R-HSA-975957
Cellular Localisation	Cytoplasm
Alternative Antibody Names	Anti-Eukaryotic Peptide Chain Release Factor Subunit 1 antibody Anti-Eukaryotic Release Factor 1 antibody Anti-Erf1 antibody Anti-Protein Cl1 antibody Anti-Tb3-1 antibody Anti-ETF1 antibody Anti-ERF1 antibody Anti-RF1 antibody Anti-SUP45L1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-ETF1 antibody (278-437) (STJ27716)