Anti-EXOSC10 antibody (586-885) (STJ119611) STJ119611 上海玉博生物科技有限公司

Anti-EXOSC10 antibody (586-885) (STJ119611)

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产品名称：Anti-EXOSC10 antibody (586-885) (STJ119611)
产品型号：STJ119611
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-EXOSC10 antibody (586-885) (STJ119611)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-EXOSC10 (586-885) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	EXOSC10
Gene ID:	5394
Uniprot ID:	EXOSX_HUMAN
Immunogen Region:	586-885
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1).
Immunogen Sequence:	VAAGVKKSGPLPSAERLENV LFGPHDCSHAPPDGYPIIPT SGSVPVQKQASLFPDEKEDN LLGTTCLIATAVITLFNEPS AEDSKKGPLTVAQKKAQNIM ESFENPFRMFLPSLGHRAPV SQAAKFDPSTKIYEISNRWK LAQVQVQKDSKEAVKKKAAE QTAAREQAKEACKAAAEQAI SVRQQVVLENAAKKRERATS DPRTTEQKQEKKRLKISKKP KDPEPPEKEFTPYDYSQSD

Function	Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA.
Protein Name	Exosome Complex Component 10 Autoantigen Pm/Scl 2 P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen Polymyositis/Scleroderma Autoantigen 100 Kda Pm/Scl-100 Polymyositis/Scleroderma Autoantigen 2
Database Links	Reactome: R-HSA-6791226
Cellular Localisation	Cytoplasm Nucleus Nucleolus Strongly Enriched In The Nucleolus And A Small Amount Has Been Found In Cytoplasm Supporting The Existence Of A Nucleolar Rna Exosome Complex Form
Alternative Antibody Names	Anti-Exosome Complex Component 10 antibody Anti-Autoantigen Pm/Scl 2 antibody Anti-P100 Polymyositis-Scleroderma Overlap Syndrome-Associated Autoantigen antibody Anti-Polymyositis/Scleroderma Autoantigen 100 Kda antibody Anti-Pm/Scl-100 antibody Anti-Polymyositis/Scleroderma Autoantigen 2 antibody Anti-EXOSC10 antibody Anti-PMSCL antibody Anti-PMSCL2 antibody Anti-RRP6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-EXOSC10 antibody (586-885) (STJ119611)