Anti-FANCD2 antibody (200-300) [S8MR] (STJ11101768) STJ11101768 上海玉博生物科技有限公司

Anti-FANCD2 antibody (200-300) [S8MR] (STJ11101768)

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产品名称：Anti-FANCD2 antibody (200-300) [S8MR] (STJ11101768)
产品型号：STJ11101768
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FANCD2 antibody (200-300) [S8MR] (STJ11101768)

产品描述

Host:	Rabbit
Applications:	WB/IP
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-FANCD2 (200-300) is suitable for use in Western Blot and Immunoprecipitation research applications.

Clonality:	Monoclonal
Clone ID:	S8MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IP 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FANCD2
Gene ID:	2177
Uniprot ID:	FACD2_HUMAN
Immunogen Region:	200-300
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200-300 of human FANCD2 (Q9BXW9).
Immunogen Sequence:	ISIAPENLQHDIITSLPEIL GDSQHADVGKELSDLLIENT SLTVPILDVLSSLRLDPNFL LKVRQLVMDKLSSIRLEDLP VIIKFILHSVTAMDTLEVIS E

Tissue Specificity	Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas (at protein level). Highly expressed in testis, where expression is restricted to maturing spermatocytes.
Post Translational Modifications	Monoubiquitinated on Lys-561 during S phase and upon genotoxic stress by FANCL in complex with E2 ligases UBE2T or UBE2W (isoform 1 and isoform 2). Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the joint intervention of the FANC core complex, including FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, and FANCM, and proteins involved in cell cycle checkpoints and DNA repair, including RPA1, ATR, CHEK1 and BRCA1, and is mediated by FANCL/PHF9. Ubiquitination is required for binding to chromatin, interaction with BRCA1, BRCA2 and MTMR15/FAN1, DNA repair, and normal cell cycle progression, but not for phosphorylation on Ser-222 or interaction with MEN1. Phosphorylated in response to various genotoxic stresses by ATM and/or ATR. Upon ionizing radiation, phosphorylated by ATM on Ser-222 and Ser-1404. Phosphorylation on Ser-222 is required for S-phase checkpoint activation, but not for ubiquitination, foci formation, or DNA repair. In contrast, phosphorylation by ATR on other sites may be required for ubiquitination and foci formation.
Function	Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
Protein Name	Fanconi Anemia Group D2 Protein Protein Facd2
Database Links	Reactome: R-HSA-6783310 Reactome: R-HSA-6796648
Cellular Localisation	Nucleus Concentrates In Nuclear Foci During S Phase And Upon Genotoxic Stress At The Onset Of Mitosis Excluded From Chromosomes And Diffuses Into The Cytoplasm Returning To The Nucleus At The End Of Cell Division Observed In A Few Spots Localized In Pairs On The Sister Chromatids Of Mitotic Chromosome Arms And Not Centromeres One On Each Chromatids These Foci Coincide With Common Fragile Sites And Could Be Sites Of Replication Fork Stalling The Foci Are Frequently Interlinked Through Blm-Associated Ultra-Fine Dna Bridges Following Aphidicolin Treatment Targets Chromatid Gaps And Breaks
Alternative Antibody Names	Anti-Fanconi Anemia Group D2 Protein antibody Anti-Protein Facd2 antibody Anti-FANCD2 antibody Anti-FACD antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FANCD2 antibody (200-300) [S8MR] (STJ11101768)