Anti-FBL antibody (222-321) [S8MR] (STJ11101258) STJ11101258 上海玉博生物科技有限公司

Anti-FBL antibody (222-321) [S8MR] (STJ11101258)

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产品名称：Anti-FBL antibody (222-321) [S8MR] (STJ11101258)
产品型号：STJ11101258
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FBL antibody (222-321) [S8MR] (STJ11101258)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Fibrillarin (222-321) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Monoclonal
Clone ID:	S8MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FBL
Gene ID:	2091
Uniprot ID:	FBRL_HUMAN
Immunogen Region:	222-321
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 222-321 of human Fibrillarin/U3 RNP (P22087).
Immunogen Sequence:	KYRMLIAMVDVIFADVAQPD QTRIVALNAHTFLRNGGHFV ISIKANCIDSTASAEAVFAS EVKKMQQENMKPQEQLTLEP YERDHAVVVGVYRPPPKVKN

Post Translational Modifications	Ubiquitinated. Ubiquitination leads to proteasomal degradation. Deubiquitinated by USP36. By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA). Acetylated by CREBBP/CBP, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me), without affecting rRNA methylation. Deacetylation by SIRT7 restores methylation of 'Gln-105' of histone H2A (H2AQ104me).
Function	S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Probably catalyzes 2'-O-methylation of U6 snRNAs in box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Protein Name	Rrna 2'-O-Methyltransferase Fibrillarin 34 Kda Nucleolar Scleroderma Antigen Histone-Glutamine Methyltransferase U6 Snrna 2'-O-Methyltransferase Fibrillarin
Database Links	Reactome: R-HSA-6790901 Reactome: R-HSA-6791226
Cellular Localisation	Nucleus Nucleolus Nucleoplasm Fibrillar Region Of The Nucleolus
Alternative Antibody Names	Anti-Rrna 2'-O-Methyltransferase Fibrillarin antibody Anti-34 Kda Nucleolar Scleroderma Antigen antibody Anti-Histone-Glutamine Methyltransferase antibody Anti-U6 Snrna 2'-O-Methyltransferase Fibrillarin antibody Anti-FBL antibody Anti-FIB1 antibody Anti-FLRN antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FBL antibody (222-321) [S8MR] (STJ11101258)