Anti-CDC42 antibody [M152] (STJA0005338) STJA0005338-100 上海玉博生物科技有限公司

Anti-CDC42 antibody [M152] (STJA0005338)

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产品名称：Anti-CDC42 antibody [M152] (STJA0005338)
产品型号：STJA0005338-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CDC42 antibody [M152] (STJA0005338)

产品描述

Host:	Mouse
Applications:	WB/ICC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Cdc42 is suitable for use in Western Blot and Immunocytochemistry research applications.

Clonality:	Monoclonal
Clone ID:	M152
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification:	Protein A Purified
Dilution Range:	WB 1:500 IHC ICC 1:50 IP
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	Cdc42
Gene ID:	64465
Uniprot ID:	CDC42_RAT
Specificity:	The antibody detects a 21 kDa* protein in human Jurkat cells and mouse brain. It does not recognize a human RhoA GST fusion protein.
Immunogen:	Clone (M152) was generated from a rat recombinant Cdc42 protein. This sequence is highly conserved in human and mouse Cdc42.

Post Translational Modifications	Phosphorylated by SRC in an EGF-dependent manner, this stimulates the binding of the Rho-GDP dissociation inhibitor RhoGDI.
Function	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups.
Protein Name	Cell Division Control Protein 42 Homolog
Database Links	Reactome: R-RNO-114604 Reactome: -RNO-182971 Reactome: -RNO-2029482 Reactome: -RNO-389359 Reactome: -RNO-3928662 Reactome: -RNO-418885 Reactome: -RNO-4420097 Reactome: -RNO-525793 Reactome: -RNO-5625970 Reactome: -RNO-5626467 Reactome: -RNO-5627123 Reactome: -RNO-5663213 Reactome: -RNO-5663220 Reactome: -RNO-5687128 Reactome: -RNO-8964616 Reactome: -RNO-9013148 Reactome: -RNO-9013149 Reactome: -RNO-9013404 Reactome: -RNO-9013406 Reactome: -RNO-9013408 Reactome: -RNO-9013420 Reactome: -RNO-9013423 Reactome: -RNO-9013424 Reactome: -RNO-983231
Cellular Localisation	Cell Membrane Lipid-Anchor Cytoplasmic Side Midbody Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Spindle Cell Projection Lamellipodium Membrane Peripheral Membrane Protein Dendrite Localizes To Spindle During Prometaphase Cells Moves To The Central Spindle As Cells Progressed Through Anaphase To Telophase Localizes At The End Of Cytokinesis In The Intercellular Bridge Formed Between Two Daughter Cells Its Localization Is Regulated By The Activities Of Guanine Nucleotide Exchange Factor Ect2 And Gtpase Activating Protein Racgap1 Colocalizes With Nek6 In The Centrosome In Its Active Gtp-Bound Form Localizes To The Leading Edge Membrane Of Migrating Dendritic Cells
Alternative Antibody Names	Anti-Cell Division Control Protein 42 Homolog antibody Anti-Cdc42 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CDC42 antibody [M152] (STJA0005338)