Anti-Cdc42-binding kinase alpha antibody (N-Term) (STJ70546) STJ70546-100 上海玉博生物科技有限公司

Anti-Cdc42-binding kinase alpha antibody (N-Term) (STJ70546)

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产品名称：Anti-Cdc42-binding kinase alpha antibody (N-Term) (STJ70546)
产品型号：STJ70546-100
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-Cdc42-binding kinase alpha antibody (N-Term) (STJ70546)

产品描述

Host:	Goat
Applications:	Pep-ELISA/IHC
Reactivity:	Human/Mouse/Rat/Dog/Cow
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Goat polyclonal antibody anti-Cdc42-binding kinase alpha (N-Term) is suitable for use in ELISA and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	IHC-3.75µg/ml ELISA-antibody detection limit dilution 1:16000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	CDC42BPA
Gene ID:	8476
Uniprot ID:	MRCKA_HUMAN
Immunogen Region:	N-Term
Accession Number:	NP_055641.3; NP_003598.2
Specificity:	This antibody is expected to recognise both reported Human isoforms (NP_055641.3 and NP_003598.2).
Immunogen Sequence:	SGEVRLRQLEQFI

Post Translational Modifications	Proteolytically cleaved by caspases upon apoptosis induction. The cleavage at Asp-478 by CASP3 increases its kinase activity (in vitro).
Function	Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells.
Protein Name	Serine/Threonine-Protein Kinase Mrck Alpha Cdc42-Binding Protein Kinase Alpha Dmpk-Like Alpha Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Alpha Mrck Alpha Myotonic Dystrophy Protein Kinase-Like Alpha
Database Links	Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013406 Reactome: R-HSA-9013409
Cellular Localisation	Cytoplasm Cell Projection Lamellipodium Displays A Dispersed Punctate Distribution And Concentrates Along The Cell Periphery Especially At The Leading Edge And Cell-Cell Junction This Concentration Is Ph-Domain Dependent Localizes In The Lamellipodium In A Fam89b/Lrap25-Dependent Manner
Alternative Antibody Names	Anti-Serine/Threonine-Protein Kinase Mrck Alpha antibody Anti-Cdc42-Binding Protein Kinase Alpha antibody Anti-Dmpk-Like Alpha antibody Anti-Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Alpha antibody Anti-Mrck Alpha antibody Anti-Myotonic Dystrophy Protein Kinase-Like Alpha antibody Anti-CDC42BPA antibody Anti-KIAA0451 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Cdc42-binding kinase alpha antibody (N-Term) (STJ70546)