Mouse WNT3A (Wingless Type MMTV Integration Site Family, Member 3A) Sandwich ELISA Kit Ready-To-Use (STJE0019492) STJE0019492 上海玉博生物科技有限公司

Mouse WNT3A (Wingless Type MMTV Integration Site Family, Member 3A) Sandwich ELISA Kit Ready-To-Use (STJE0019492)

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产品名称：Mouse WNT3A (Wingless Type MMTV Integration Site Family, Member 3A) Sandwich ELISA Kit Ready-To-Use (STJE0019492)
产品型号：STJE0019492
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Mouse WNT3A (Wingless Type MMTV Integration Site Family, Member 3A) Sandwich ELISA Kit Ready-To-Use (STJE0019492)

产品描述

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	6.7pg/mL
Detection Limit:	15.6-1000pg/mL
Short Description:	This WNT3A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Wnt3a
Gene ID:	22416
Uniprot ID:	WNT3A_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Tissue Specificity	Dorsal portion of the neural tube (developing roof plate), and mesenchyme tissue surrounding the umbilical veins.
Post Translational Modifications	Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT3A. Disulfide bonds have critical and distinct roles in secretion and activity. Loss of each conserved cysteine in WNT3A results in high molecular weight oxidized Wnt oligomers, which are formed through inter-Wnt disulfide bonding. Palmitoleoylation by PORCN is required for efficient binding to frizzled receptors. Palmitoleoylation is required for proper trafficking to cell surface, vacuolar acidification is critical to release palmitoleoylated WNT3A from WLS in secretory vesicles. Depalmitoleoylated by NOTUM, leading to inhibit Wnt signaling pathway, possibly by promoting disulfide bond formation and oligomerization.
Function	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro).
Protein Name	Protein Wnt-3a
Database Links	Reactome: R-MMU-201681 Reactome: -MMU-3238698 Reactome: -MMU-4641262 Reactome: -MMU-4641263
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative ELISA Names	Protein Wnt-3a ELISA kit Wnt3a ELISA kit Wnt-3a ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Mouse WNT3A (Wingless Type MMTV Integration Site Family, Member 3A) Sandwich ELISA Kit Ready-To-Use (STJE0019492)