Mouse XPC (Xeroderma Pigmentosum, Complementation Group C) Sandwich ELISA Kit (STJE0013124) STJE0013124 上海玉博生物科技有限公司

Mouse XPC (Xeroderma Pigmentosum, Complementation Group C) Sandwich ELISA Kit (STJE0013124)

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产品名称：Mouse XPC (Xeroderma Pigmentosum, Complementation Group C) Sandwich ELISA Kit (STJE0013124)
产品型号：STJE0013124
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Mouse XPC (Xeroderma Pigmentosum, Complementation Group C) Sandwich ELISA Kit (STJE0013124)

产品描述

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.061ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This XPC Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Xpc
Gene ID:	22591
Uniprot ID:	XPC_MOUSE
Sample Type:	tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications	Ubiquitinated upon UV irradiation.the ubiquitination requires the UV-DDB complex, appears to be reversible and does not serve as a signal for degradation. Ubiquitinated by RNF11 via 'Lys-63'-linked ubiquitination. Ubiquitination by RNF111 is polysumoylation-dependent and promotes nucleotide excision repair. Sumoylated.sumoylation promotes ubiquitination by RNF111.
Function	Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER.it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1. In absence of DNA repair, the XPC complex also acts as a transcription coactivator: XPC interacts with the DNA-binding transcription factor E2F1 at a subset of promoters to recruit KAT2A and histone acetyltransferase complexes (HAT). KAT2A recruitment specifically promotes acetylation of histone variant H2A.Z.1/H2A.Z, but not H2A.Z.2/H2A.V, thereby promoting expression of target genes.
Protein Name	Dna Repair Protein Complementing Xp-C Cells Homolog Xeroderma Pigmentosum Group C-Complementing Protein Homolog P125
Database Links	Reactome: R-MMU-3108214 Reactome: -MMU-5696394 Reactome: -MMU-5696395
Cellular Localisation	Nucleus Chromosome Cytoplasm Omnipresent In The Nucleus And Consistently Associates With And Dissociates From Dna In The Absence Of Dna Damage Continuously Shuttles Between The Cytoplasm And The Nucleus Which Is Impeded By The Presence Of Ner Lesions
Alternative ELISA Names	Dna Repair Protein Complementing Xp-C Cells Homolog ELISA kit Xeroderma Pigmentosum Group C-Complementing Protein Homolog ELISA kit P125 ELISA kit Xpc ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Mouse XPC (Xeroderma Pigmentosum, Complementation Group C) Sandwich ELISA Kit (STJE0013124)