Mouse YAP1 (Yes Associated Protein 1) Sandwich ELISA Kit (STJE0013135) STJE0013135 上海玉博生物科技有限公司

Mouse YAP1 (Yes Associated Protein 1) Sandwich ELISA Kit (STJE0013135)

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产品名称：Mouse YAP1 (Yes Associated Protein 1) Sandwich ELISA Kit (STJE0013135)
产品型号：STJE0013135
产品展商：ST john's laboratory
产品文档：无相关文档

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Mouse YAP1 (Yes Associated Protein 1) Sandwich ELISA Kit (STJE0013135)

产品描述

Applications:	ELISA
Reactivity:	Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity:	0.056ng/mL
Detection Limit:	0.156-10ng/mL
Short Description:	This YAP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Yap1
Gene ID:	22601
Uniprot ID:	YAP1_MOUSE
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Isoforms lacking the transactivation domain seen in striatal neurons (at protein level). Ubiquitous. Isoform 2 is expressed at higher levels in the neural tissues. In the embryo, it is expressed in brain, eye, and the maxillary and frontonasal components of the primary palate.
Post Translational Modifications	Phosphorylated by LATS1 and LATS2.leading to cytoplasmic translocation and inactivation. Phosphorylated by ABL1.leading to YAP1 stabilization, enhanced interaction with TP73 and recruitment onto proapoptotic genes.in response to DNA damage. Phosphorylation at Ser-385 and Ser-388 by CK1 is triggered by previous phosphorylation at Ser-382 by LATS proteins and leads to YAP1 ubiquitination by SCF(beta-TRCP) E3 ubiquitin ligase and subsequent degradation. Phosphorylated at Thr-104, Ser-123, Ser-352 and Thr-397 by MAPK8/JNK1 and MAPK9/JNK2, which is required for the regulation of apoptosis by YAP1. Ubiquitinated by SCF(beta-TRCP) E3 ubiquitin ligase.
Function	Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization. Plays a key role in controlling cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Suppresses ciliogenesis via acting as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. In conjunction with WWTR1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation.
Protein Name	Transcriptional Coactivator Yap1 Yes-Associated Protein 1 Protein Yorkie Homolog Yes-Associated Protein Yap65 Homolog
Database Links	Reactome: R-MMU-1251985 Reactome: -MMU-2028269 Reactome: -MMU-2032785 Reactome: -MMU-8939236 Reactome: -MMU-8951671
Cellular Localisation	Cytoplasm Nucleus Cell Junction Both Phosphorylation And Cell Density Can Regulate Its Subcellular Localization Phosphorylation Sequesters It In The Cytoplasm By Inhibiting Its Translocation Into The Nucleus At Low Density Predominantly Nuclear And Is Translocated To The Cytoplasm At High Density Ptpn14 Induces Translocation From The Nucleus To The Cytoplasm Localized Mainly To The Nucleus In The Early Stages Of Embryo Development With Expression Becoming Evident In The Cytoplasm At The Blastocyst And Epiblast Stages
Alternative ELISA Names	Transcriptional Coactivator Yap1 ELISA kit Yes-Associated Protein 1 ELISA kit Protein Yorkie Homolog ELISA kit Yes-Associated Protein Yap65 Homolog ELISA kit Yap1 ELISA kit Yap ELISA kit Yap65 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Mouse YAP1 (Yes Associated Protein 1) Sandwich ELISA Kit (STJE0013135)