Anti-FCGR3A antibody (90-170 aa) (STJ192519) STJ192519 上海玉博生物科技有限公司

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产品名称：Anti-FCGR3A antibody (90-170 aa) (STJ192519)
产品型号：STJ192519
产品展商：ST john's laboratory
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简单介绍

Anti-FCGR3A antibody (90-170 aa) (STJ192519)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Low affinity immunoglobulin gamma Fc region receptor III-A (90-170 aa) is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000 ELISA 1:5000-20000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FCGR3A
Gene ID:	2214
Uniprot ID:	FCG3A_HUMAN
Immunogen Region:	90-170 aa
Specificity:	FCG3A Polyclonal Antibody detects endogenous levels of protein.
Immunogen:	Synthesized peptide derived from the human protein at the amino acid range 90-170

Post Translational Modifications	Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms. Undergoes rapid ectodomain shedding upon NK cell stimulation. The soluble form is produced by a proteolytic cleavage mediated by ADAM17. Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis. Phosphorylated at RSSTR motif by PKC. The relevant physiological PKCs might be PRKCI, PRKCG, PRKCE, PRKCH and PRKCQ.
Function	Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger. Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. Involved in the generation of memory-like adaptive NK cells capable to produce high amounts of IFNG and to efficiently eliminate virus-infected cells via ADCC. Regulates NK cell survival and proliferation, in particular by preventing NK cell progenitor apoptosis. Fc-binding subunit that associates with CD247 and/or FCER1G adapters to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation. The ITAM-dependent signaling coupled to receptor phosphorylation by PKC mediates robust intracellular calcium flux that leads to production of pro-inflammatory cytokines, whereas in the absence of receptor phosphorylation it mainly activates phosphatidylinositol 3-kinase signaling leading to cell degranulation. Costimulates NK cells and trigger lysis of target cells independently of IgG binding. Mediates the antitumor activities of therapeutic antibodies. Upon ligation on monocytes triggers TNFA-dependent ADCC of IgG-coated tumor cells. Mediates enhanced ADCC in response to afucosylated IgGs. (Microbial infection) Involved in Dengue virus pathogenesis via antibody-dependent enhancement (ADE) mechanism. Secondary infection with Dengue virus triggers elevated levels of afucosylated non-neutralizing IgG1s with reactivity to viral envelope/E protein. Viral antigen-IgG1 complexes bind with high affinity to FCGR3A, facilitating virus entry in myeloid cells and subsequent viral replication.
Protein Name	Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A Igg Fc Receptor Iii-A Cd16-Ii Cd16a Antigen Fc-Gamma Riii-Alpha Fc-Gamma Riii Fc-Gamma Riiia Fcriii Fcriiia Fcgammariiia Fcr-10 Igg Fc Receptor Iii-2 Cd Antigen Cd16a
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-2029481 Reactome: R-HSA-2029482 Reactome: R-HSA-2029485 Reactome: R-HSA-9664323 Reactome: R-HSA-9664422
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Secreted Exists Also As A Soluble Receptor
Alternative Antibody Names	Anti-Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A antibody Anti-Igg Fc Receptor Iii-A antibody Anti-Cd16-Ii antibody Anti-Cd16a Antigen antibody Anti-Fc-Gamma Riii-Alpha antibody Anti-Fc-Gamma Riii antibody Anti-Fc-Gamma Riiia antibody Anti-Fcriii antibody Anti-Fcriiia antibody Anti-Fcgammariiia antibody Anti-Fcr-10 antibody Anti-Igg Fc Receptor Iii-2 antibody Anti-Cd Antigen Cd16a antibody Anti-FCGR3A antibody Anti-CD16A antibody Anti-FCG3 antibody Anti-FCGR3 antibody Anti-IGFR3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FCGR3A antibody (90-170 aa) (STJ192519)