Anti-FCHO2 antibody (1-300) (STJ117155) STJ117155 上海玉博生物科技有限公司

Anti-FCHO2 antibody (1-300) (STJ117155)

简单介绍

Anti-FCHO2 antibody (1-300) (STJ117155)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FCHO2 (1-300) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FCHO2
Gene ID:	115548
Uniprot ID:	FCHO2_HUMAN
Immunogen Region:	1-300
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FCHO2 (NP_620137.2).
Immunogen Sequence:	MVMAYFVENFWGEKNSGFDV LYHNMKHGQISTKELADFVR ERATIEEAYSRSMTKLAKSA SNYSQLGTFAPVWDVFKTST EKLANCHLDLVRKLQELIKE VQKYGEEQVKSHKKTKEEVA GTLEAVQTIQSITQALQKSK ENYNAKCVEQERLKKEGATQ REIEKAAVKSKKATDTYKLY VEKYALAKADFEQKMTETAQ KFQDIEETHLIHIKEIIGSL SNAIKEIHLQIGQVHEEFI

Post Translational Modifications	Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination.
Function	Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
Protein Name	F-Bar Domain Only Protein 2
Database Links	Reactome: R-HSA-8856825 Reactome: R-HSA-8856828
Cellular Localisation	Membrane Clathrin-Coated Pit Peripheral Membrane Protein Cytoplasmic Side Associated With Forming But Not Mature Clathrin-Coated Vesicles The Recruitment To Coated-Pits Precede The One Of Clathrin And The Adaptor Protein Complex Ap-2
Alternative Antibody Names	Anti-F-Bar Domain Only Protein 2 antibody Anti-FCHO2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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