Anti-FEN1 antibody (50-380) (STJ23646) STJ23646 上海玉博生物科技有限公司

Anti-FEN1 antibody (50-380) (STJ23646)

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产品名称：Anti-FEN1 antibody (50-380) (STJ23646)
产品型号：STJ23646
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FEN1 antibody (50-380) (STJ23646)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/IP
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FEN1 (50-380) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:10-1:100 IP 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FEN1
Gene ID:	2237
Uniprot ID:	FEN1_HUMAN
Immunogen Region:	50-380
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 50-380 of human FEN-1 (NP_004102.1).
Immunogen Sequence:	GDVLQNEEGETTSHLMGMFY RTIRMMENGIKPVYVFDGKP PQLKSGELAKRSERRAEAEK QLQQAQAAGAEQEVEKFTKR LVKVTKQHNDECKHLLSLMG IPYLDAPSEAEASCAALVKA GKVYAAATEDMDCLTFGSPV LMRHLTASEAKKLPIQEFHL SRILQELGLNQEQFVDLCIL LGSDYCESIRGIGPKRAVDL IQKHKSIEEIVRRLDPNKYP VPENWLHKEAHQLFLEPEV

Post Translational Modifications	Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA. Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA.
Function	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Protein Name	Flap Endonuclease 1 Fen-1 Dnase Iv Flap Structure-Specific Endonuclease 1 Maturation Factor 1 Mf1 Hfen-1
Database Links	Reactome: R-HSA-110362 Reactome: R-HSA-162594 Reactome: R-HSA-174437 Reactome: R-HSA-5651801 Reactome: R-HSA-5685939 Reactome: R-HSA-69166
Cellular Localisation	Isoform 1: Nucleus Nucleolus Nucleus Nucleoplasm Resides Mostly In The Nucleoli And Relocalizes To The Nucleoplasm Upon Dna Damage Isoform Fenmit: Mitochondrion
Alternative Antibody Names	Anti-Flap Endonuclease 1 antibody Anti-Fen-1 antibody Anti-Dnase Iv antibody Anti-Flap Structure-Specific Endonuclease 1 antibody Anti-Maturation Factor 1 antibody Anti-Mf1 antibody Anti-Hfen-1 antibody Anti-FEN1 antibody Anti-RAD2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FEN1 antibody (50-380) (STJ23646)