Anti-FER antibody (200-450) (STJ111789) STJ111789 上海玉博生物科技有限公司

Anti-FER antibody (200-450) (STJ111789)

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产品名称：Anti-FER antibody (200-450) (STJ111789)
产品型号：STJ111789
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FER antibody (200-450) (STJ111789)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FER (200-450) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FER
Gene ID:	2241
Uniprot ID:	FER_HUMAN
Immunogen Region:	200-450
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human FER (NP_005237.2).
Immunogen Sequence:	YDITLPLLLDSLQKMQEEMI KALKGIFDEYSQITSLVTEE IVNVHKEIQMSVEQIDPSTE YNNFIDVHRTTAAKEQEIEF DTSLLEENENLQANEIMWNN LTAESLQVMLKTLAEELMQT QQMLLNKEEAVLELEKRIEE SSETCEKKSDIVLLLSQKQA LEELKQSVQQLRCTEAKFSA QKELLEQKVQENDGKEPPPV VNYEEDARSVTSMERKERLS KFESIRHSIAGIIRSPKSA

Tissue Specificity	Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.
Post Translational Modifications	Autophosphorylated. Polyubiquitinated.this leads to proteasomal degradation.
Function	Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
Protein Name	Tyrosine-Protein Kinase Fer Feline Encephalitis Virus-Related Kinase Fer Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer Proto-Oncogene C-Fer Tyrosine Kinase 3 P94-Fer
Database Links	Reactome: R-HSA-1433557
Cellular Localisation	Cytoplasm Cytoskeleton Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Projection Cell Junction Membrane Nucleus Cell Cortex Associated With The Chromatin Detected On Microtubules In Polarized And Motile Vascular Endothelial Cells Colocalizes With F-Actin At The Cell Cortex Colocalizes With Pecam1 And Ctnnd1 At Nascent Cell-Cell Contacts
Alternative Antibody Names	Anti-Tyrosine-Protein Kinase Fer antibody Anti-Feline Encephalitis Virus-Related Kinase Fer antibody Anti-Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer antibody Anti-Proto-Oncogene C-Fer antibody Anti-Tyrosine Kinase 3 antibody Anti-P94-Fer antibody Anti-FER antibody Anti-TYK3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FER antibody (200-450) (STJ111789)