Anti-FERMT3 antibody (1-270) (STJ110149) STJ110149 上海玉博生物科技有限公司

Anti-FERMT3 antibody (1-270) (STJ110149)

简单介绍

Anti-FERMT3 antibody (1-270) (STJ110149)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FERMT3 (1-270) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FERMT3
Gene ID:	83706
Uniprot ID:	URP2_HUMAN
Immunogen Region:	1-270
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human FERMT3 (NP_113659.3).
Immunogen Sequence:	MAGMKTASGDYIDSSWELRV FVGEEDPEAESVTLRVTGES HIGGVLLKIVEQINRKQDWS DHAIWWEQKRQWLLQTHWTL DKYGILADARLFFGPQHRPV ILRLPNRRALRLRASFSQPL FQAVAAICRLLSIRHPEELS LLRAPEKKEKKKKEKEPEEE LYDLSKVVLAGGVAPALFRG MPAHFSDSAQTEACYHMLSR PQPPPDPLLLQRLPRPSSLS DKTQLHSRWLDSSRCLMQQ

Tissue Specificity	Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
Function	Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
Protein Name	Fermitin Family Homolog 3 Kindlin-3 Mig2-Like Protein Unc-112-Related Protein 2
Database Links	Reactome: R-HSA-114608
Cellular Localisation	Cell Projection Podosome Present In The F-Actin Surrounding Ring Structure Of Podosomes Which Are Specialized Adhesion Structures Of Hematopoietic Cells
Alternative Antibody Names	Anti-Fermitin Family Homolog 3 antibody Anti-Kindlin-3 antibody Anti-Mig2-Like Protein antibody Anti-Unc-112-Related Protein 2 antibody Anti-FERMT3 antibody Anti-KIND3 antibody Anti-MIG2B antibody Anti-URP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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