Anti-FES antibody (131-180 aa) (STJ93058) STJ93058 上海玉博生物科技有限公司

Anti-FES antibody (131-180 aa) (STJ93058)

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产品名称：Anti-FES antibody (131-180 aa) (STJ93058)
产品型号：STJ93058
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FES antibody (131-180 aa) (STJ93058)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Tyrosine-protein kinase Fes/Fps (131-180 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FES
Gene ID:	2242
Uniprot ID:	FES_HUMAN
Immunogen Region:	131-180 aa
Specificity:	Fes Polyclonal Antibody detects endogenous levels of Fes protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human FES at the amino acid range 131-180

Post Translational Modifications	Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.
Function	Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Protein Name	Tyrosine-Protein Kinase Fes/Fps Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog Proto-Oncogene C-Fes Proto-Oncogene C-Fps P93c-Fes
Database Links	Reactome: R-HSA-1433557 Reactome: R-HSA-399954 Reactome: R-HSA-399955 Reactome: R-HSA-399956
Cellular Localisation	Cytoplasm Cytosol Cytoskeleton Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cytoplasmic Vesicle Golgi Apparatus Cell Junction Focal Adhesion Distributed Throughout The Cytosol When The Kinase Is Not Activated Association With Microtubules Requires Activation Of The Kinase Activity Shuttles Between Focal Adhesions And Cell-Cell Contacts In Epithelial Cells Recruited To The Lateral Cell Membrane In Polarized Epithelial Cells By Interaction With Phosphorylated Ezr Detected At Tubular Membrane Structures In The Cytoplasm And At The Cell Periphery
Alternative Antibody Names	Anti-Tyrosine-Protein Kinase Fes/Fps antibody Anti-Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog antibody Anti-Proto-Oncogene C-Fes antibody Anti-Proto-Oncogene C-Fps antibody Anti-P93c-Fes antibody Anti-FES antibody Anti-FPS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FES antibody (131-180 aa) (STJ93058)