Anti-FFAR1 antibody (C-Term) (STJ118807) STJ118807 上海玉博生物科技有限公司

Anti-FFAR1 antibody (C-Term) (STJ118807)

简单介绍

Anti-FFAR1 antibody (C-Term) (STJ118807)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FFAR1 (C-Term) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FFAR1
Gene ID:	2864
Uniprot ID:	FFAR1_HUMAN
Immunogen Region:	C-Term
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human FFAR1 (NP_005294.1).
Immunogen Sequence:	FCYVGCLRALARSGLTHRRK LRAAWVAGGALLTLLLCVGP YNASNVASFLYPNLGGSWRK LGLITGAWSVVLNPLVTGYL GRGPGLKTVCAARTQGGKSQ K

Tissue Specificity	Detected in brain and pancreas. Detected in pancreatic beta cells.
Function	G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis.receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation.
Protein Name	Free Fatty Acid Receptor 1 G-Protein Coupled Receptor 40
Database Links	Reactome: R-HSA-381771 Reactome: R-HSA-400511 Reactome: R-HSA-416476 Reactome: R-HSA-434316 Reactome: R-HSA-444209
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Free Fatty Acid Receptor 1 antibody Anti-G-Protein Coupled Receptor 40 antibody Anti-FFAR1 antibody Anti-GPR40 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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