Anti-CDK4 antibody [ZR394] (STJ180606) STJ180606 上海玉博生物科技有限公司

Anti-CDK4 antibody [ZR394] (STJ180606)

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产品名称：Anti-CDK4 antibody [ZR394] (STJ180606)
产品型号：STJ180606
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CDK4 antibody [ZR394] (STJ180606)

产品描述

Host:	Rabbit
Applications:	IHC-P
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-CDK4 is suitable for use in Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	ZR394
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification:	Affinity purified
Dilution Range:	1:100-200
Storage Instruction:	Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.

Specificity:	Urothelial carcinoma, well-differentiated liposarcoma
Immunogen:	Recombinant fragment corresponding to N-terminal of human CDK4 protein

Background

Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. It is essential for the G1-to S-phase transition during the cell cycle and its expression is primarily controlled at the transcriptional level. CCND1-CDK4 axis is not only critical in glial tumor cells but also in stromal-derived cells in the surrounding tumor microenvironment that are vital to sustaining tumor outgrowth. CDK4 is highly expressed in highly differentiated and dedifferentiated liposarcomas but rarely expressed in other benign liposarcomas and other sarcomas. CDK4 and MDM2 combined to differentiate between highly differentiated liposarcoma (+) , dedifferentiated liposarcoma (+) , and myxoid liposarcoma, pleomorphic liposarcoma, spindle lipoma, pleomorphic lipoma, and other high-grade sarcomas.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CDK4 antibody [ZR394] (STJ180606)