Anti-Fibrinogen alpha chain antibody (700-800) [S3MR] (STJ11103073) STJ11103073 上海玉博生物科技有限公司

Anti-Fibrinogen alpha chain antibody (700-800) [S3MR] (STJ11103073)

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产品名称：Anti-Fibrinogen alpha chain antibody (700-800) [S3MR] (STJ11103073)
产品型号：STJ11103073
产品展商：ST john's laboratory
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简单介绍

Anti-Fibrinogen alpha chain antibody (700-800) [S3MR] (STJ11103073)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Fibrinogen alpha chain (FGA) (700-800) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Monoclonal
Clone ID:	S3MR
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FGA
Gene ID:	2243
Uniprot ID:	FIBA_HUMAN
Immunogen Region:	700-800
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 700-800 of human Fibrinogen alpha chain (FGA) (FGA) (P02671).
Immunogen Sequence:	NDEGEGEFWLGNDYLHLLTQ RGSVLRVELEDWAGNEAYAE YHFRVGSEAEGYALQVSSYE GTAGDALIEGSVEEGAEYTS HNNMQFSTFDRDADQWEENC A

Tissue Specificity	Detected in blood plasma (at protein level).
Post Translational Modifications	The alpha chain is normally not N-glycosylated, even though glycosylation at Asn-686 was observed when a fragment of the protein was expressed in insect cells. It is well known that heterologous expression of isolated domains can lead to adventitious protein modifications. Besides, glycosylation at Asn-686 is supported by large-scale glycoproteomics studies, but the evidence is still quite tenuous. Most likely, Asn-686 is not glycosylated in the healthy human body, or only with low efficiency. O-glycosylated. Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers. About one-third of the alpha chains in the molecules in blood were found to be phosphorylated. Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. Phosphorylated by FAM20C in the extracellular medium.
Function	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Protein Name	Fibrinogen Alpha Chain Cleaved Into - Fibrinopeptide A - Fibrinogen Alpha Chain
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-1236974 Reactome: R-HSA-140875 Reactome: R-HSA-166058 Reactome: R-HSA-216083 Reactome: R-HSA-354192 Reactome: R-HSA-354194 Reactome: R-HSA-372708 Reactome: R-HSA-381426 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5674135 Reactome: R-HSA-5686938 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-8957275 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-977225
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Fibrinogen Alpha Chain Cleaved Into - Fibrinopeptide A - Fibrinogen Alpha Chain antibody Anti-FGA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-Fibrinogen alpha chain antibody (700-800) [S3MR] (STJ11103073)