Anti-CDKN1A antibody (1-159) (STJ11103324) STJ11103324 上海玉博生物科技有限公司

Anti-CDKN1A antibody (1-159) (STJ11103324)

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产品名称：Anti-CDKN1A antibody (1-159) (STJ11103324)
产品型号：STJ11103324
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-CDKN1A antibody (1-159) (STJ11103324)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CDKN1A (1-159) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	Cdkn1a
Gene ID:	12575
Uniprot ID:	CDN1A_MOUSE
Immunogen Region:	1-159
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-159 of mouse CDKN1A (NP_031695.1).
Immunogen Sequence:	MSNPGDVRPVPHRSKVCRCL FGPVDSEQLRRDCDALMAGC LQEARERWNFDFVTETPLEG NFVWERVRSLGLPKVYLSPG SRSRDDLGGDKRPSTSSALL QGPAPEDHVALSLSCTLVSE RPEDSPGGPGTSQGRKRRQT SLTDFYHSKRRLVFCKRKP

Post Translational Modifications	Phosphorylation of Thr-140 or Ser-141 impairs binding to PCNA. Phosphorylation at Ser-112 by GSK3-beta enhances ubiquitination by the DCX(DTL) complex. Phosphorylation of Thr-140 by PIM2 enhances its stability and inhibits cell proliferation. Phosphorylation of Thr-140 by PIM1 results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. UV radiation-induced phosphorylation at Ser-78 and Ser-141 by NUAK1 leads to its degradation. Ubiquitinated by MKRN1.leading to polyubiquitination and 26S proteasome-dependent degradation. Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, leading to its degradation during S phase or following UV irradiation. Ubiquitination by the DCX(DTL) complex is essential to control replication licensing and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. Ubiquitination at Ser-2 leads to degradation by the proteasome pathway. Ubiquitinated by RNF114.leading to proteasomal degradation. Acetylation leads to protein stability. Acetylated in vitro on Lys-136, Lys-149, Lys-156 and Lys-158. Deacetylation by HDAC1 is prevented by competitive binding of C10orf90/FATS to HDAC1.
Function	May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest. Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest. Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.
Protein Name	Cyclin-Dependent Kinase Inhibitor 1 Cdk-Interacting Protein 1 Melanoma Differentiation-Associated Protein P21
Database Links	Reactome: R-MMU-187577 Reactome: -MMU-198323 Reactome: -MMU-2559582 Reactome: -MMU-2559586 Reactome: -MMU-6804116 Reactome: -MMU-69202 Reactome: -MMU-69231 Reactome: -MMU-69563 Reactome: -MMU-69656 Reactome: -MMU-8852276 Reactome: -MMU-9616222
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Cyclin-Dependent Kinase Inhibitor 1 antibody Anti-Cdk-Interacting Protein 1 antibody Anti-Melanoma Differentiation-Associated Protein antibody Anti-P21 antibody Anti-Cdkn1a antibody Anti-Cip1 antibody Anti-Waf1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-CDKN1A antibody (1-159) (STJ11103324)