Anti-FKBP4 antibody (220-459) (STJ27610) STJ27610 上海玉博生物科技有限公司

Anti-FKBP4 antibody (220-459) (STJ27610)

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产品名称：Anti-FKBP4 antibody (220-459) (STJ27610)
产品型号：STJ27610
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FKBP4 antibody (220-459) (STJ27610)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/IP
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FKBP4 (220-459) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:100 IP 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FKBP4
Gene ID:	2288
Uniprot ID:	FKBP4_HUMAN
Immunogen Region:	220-459
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 220-459 of human FKBP52/FKBP52/FKBP4 (NP_002005.1).
Immunogen Sequence:	YLKPSYAFGSVGKEKFQIPP NAELKYELHLKSFEKAKESW EMNSEEKLEQSTIVKERGTV YFKEGKYKQALLQYKKIVSW LEYESSFSNEEAQKAQALRL ASHLNLAMCHLKLQAFSAAI ESCNKALELDSNNEKGLFRR GEAHLAVNDFELARADFQKV LQLYPNNKAAKTQLAVCQQR IRRQLAREKKLYANMFERLA EEENKAKAEASSGDHPTDTE MKEEQKSNTAGSQSQVETE

Tissue Specificity	Widely expressed.
Post Translational Modifications	Phosphorylation by CK2 results in loss of HSP90 binding activity.
Function	Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria.
Protein Name	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 Ppiase Fkbp4 51 Kda Fk506-Binding Protein Fkbp51 52 Kda Fk506-Binding Protein 52 Kda Fkbp Fkbp-52 59 Kda Immunophilin P59 Fk506-Binding Protein 4 Fkbp-4 Fkbp59 Hsp-Binding Immunophilin Hbi Immunophilin Fkbp52 Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed
Database Links	Reactome: R-HSA-3371497 Reactome: R-HSA-3371568 Reactome: R-HSA-8939211 Reactome: R-HSA-9018519 Reactome: R-HSA-9679191
Cellular Localisation	Cytoplasm Cytosol Mitochondrion Nucleus Cytoskeleton Cell Projection Axon Shuttles From Mitochondria To Nucleus Co-Localizes In Mitochondria With The Glucocorticoid Receptor Colocalized With Mapt/Tau In The Distal Part Of The Primary Cortical Neurons
Alternative Antibody Names	Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 antibody Anti-Ppiase Fkbp4 antibody Anti-51 Kda Fk506-Binding Protein antibody Anti-Fkbp51 antibody Anti-52 Kda Fk506-Binding Protein antibody Anti-52 Kda Fkbp antibody Anti-Fkbp-52 antibody Anti-59 Kda Immunophilin antibody Anti-P59 antibody Anti-Fk506-Binding Protein 4 antibody Anti-Fkbp-4 antibody Anti-Fkbp59 antibody Anti-Hsp-Binding Immunophilin antibody Anti-Hbi antibody Anti-Immunophilin Fkbp52 antibody Anti-Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed antibody Anti-FKBP4 antibody Anti-FKBP52 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FKBP4 antibody (220-459) (STJ27610)