Anti-FKBP8 antibody (60-270) (STJ29165) STJ29165 上海玉博生物科技有限公司

Anti-FKBP8 antibody (60-270) (STJ29165)

简单介绍

Anti-FKBP8 antibody (60-270) (STJ29165)

产品描述

Host:	Rabbit
Applications:	WB/IF/IP
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FKBP8 (60-270) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:100 IP 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FKBP8
Gene ID:	23770
Uniprot ID:	FKBP8_HUMAN
Immunogen Region:	60-270
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human FKBP38/FKBP38/FKBP8 (NP_036313.3).
Immunogen Sequence:	QPPAEEAEQPGALAREFLAA MEPEPAPAPAPEEWLDILGN GLLRKKTLVPGPPGSSRPVK GQVVTVHLQTSLENGTRVQE EPELVFTLGDCDVIQALDLS VPLMDVGETAMVTADSKYCY GPQGSRSPYIPPHAALCLEV TLKTAVDGPDLEMLTGQERV ALANRKRECGNAHYQRADFV LAANSYDLAIKAITSSAKVD MTFEEEAQLLQ

Tissue Specificity	Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.
Post Translational Modifications	Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Function	Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV).
Protein Name	Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8 Ppiase Fkbp8 38 Kda Fk506-Binding Protein 38 Kda Fkbp Fkbp-38 Hfkbp38 Fk506-Binding Protein 8 Fkbp-8 Fkbpr38 Rotamase
Database Links	Reactome: R-HSA-5689880
Cellular Localisation	Mitochondrion Mitochondrion Membrane Single-Pass Membrane Protein Cytoplasmic Side Isoform 1: Mitochondrion Membrane Isoform 3: Mitochondrion Membrane
Alternative Antibody Names	Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8 antibody Anti-Ppiase Fkbp8 antibody Anti-38 Kda Fk506-Binding Protein antibody Anti-38 Kda Fkbp antibody Anti-Fkbp-38 antibody Anti-Hfkbp38 antibody Anti-Fk506-Binding Protein 8 antibody Anti-Fkbp-8 antibody Anti-Fkbpr38 antibody Anti-Rotamase antibody Anti-FKBP8 antibody Anti-FKBP38 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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