Anti-FLCN antibody (341-579) (STJ116732) STJ116732 上海玉博生物科技有限公司

Anti-FLCN antibody (341-579) (STJ116732)

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产品名称：Anti-FLCN antibody (341-579) (STJ116732)
产品型号：STJ116732
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FLCN antibody (341-579) (STJ116732)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FLCN (341-579) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FLCN
Gene ID:	201163
Uniprot ID:	FLCN_HUMAN
Immunogen Region:	341-579
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 341-579 of human FLCN (NP_659434.2).
Immunogen Sequence:	RKLPVFKSLRHMRQVLGAPS FRMLAWHVLMGNQVIWKSRD VDLVQSAFEVLRTMLPVGCV RIIPYSSQYEEAYRCNFLGL SPHVQIPPHVLSSEFAVIVE VHAAARSTLHPVGCEDDQSL SKYEFVVTSGSPVAADRVGP TILNKIEAALTNQNLSVDVV DQCLVCLKEEWMNKVKVLFK FTKVDSRPKEDTQKLLSILG ASEEDNVKLLKFWMTGLSKT YKSHLMSTVRSPTASESRN

Tissue Specificity	Expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach.
Post Translational Modifications	Phosphorylation by ULK1 modulates the interaction with GABARAP and is required to regulate autophagy.
Function	Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis. GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3. Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1. The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients. Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1. In low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, inactivates mTORC1 and maximizes nuclear translocation of TFEB and TFE3. Upon amino acid restimulation, RagA/RRAGA (or RagB/RRAGB) nucleotide exchange promotes disassembly of the LFC complex and liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent cytoplasmic retention of TFEB and TFE3. Indirectly acts as a positive regulator of Wnt signaling by promoting mTOR-dependent cytoplasmic retention of MiT/TFE factor TFE3. Required for the exit of hematopoietic stem cell from pluripotency by promoting mTOR-dependent cytoplasmic retention of TFE3, thereby increasing Wnt signaling. Acts as an inhibitor of browning of adipose tissue by regulating mTOR-dependent cytoplasmic retention of TFE3. Involved in the control of embryonic stem cells differentiation.together with LAMTOR1 it is necessary to recruit and activate RagC/RRAGC and RagD/RRAGD at the lysosomes, and to induce exit of embryonic stem cells from pluripotency via non-canonical, mTOR-independent TFE3 inactivation. In response to flow stress, regulates STK11/LKB1 accumulation and mTORC1 activation through primary cilia: may act by recruiting STK11/LKB1 to primary cilia for activation of AMPK resided at basal bodies, causing mTORC1 down-regulation. Together with FNIP1 and/or FNIP2, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy. Required for starvation-induced perinuclear clustering of lysosomes by promoting association of RILP with its effector RAB34. Regulates glycolysis by binding to lactate dehydrogenase LDHA, acting as an uncompetitive inhibitor.
Protein Name	Folliculin Bhd Skin Lesion Fibrofolliculoma Protein Birt-Hogg-Dube Syndrome Protein
Database Links	Reactome: R-HSA-9639288
Cellular Localisation	Lysosome Membrane Cytoplasm Cytosol Cell Projection Cilium Cytoskeleton Microtubule Organizing Center Centrosome Spindle Nucleus Localizes To Lysosome Membrane In Amino Acid-Depleted Conditions And Relocalizes To The Cytosol Upon Refeeding Colocalizes With Fnip1 And Fnip2 In The Cytoplasm Also Localizes To Motile And Non-Motile Cilia Centrosomes And The Mitotic Spindle
Alternative Antibody Names	Anti-Folliculin antibody Anti-Bhd Skin Lesion Fibrofolliculoma Protein antibody Anti-Birt-Hogg-Dube Syndrome Protein antibody Anti-FLCN antibody Anti-BHD antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FLCN antibody (341-579) (STJ116732)