Anti-FLNB antibody (STJA0008150) STJA0008150 上海玉博生物科技有限公司

Anti-FLNB antibody (STJA0008150)

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产品名称：Anti-FLNB antibody (STJA0008150)
产品型号：STJA0008150
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FLNB antibody (STJA0008150)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Filamin-B is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FLNB
Gene ID:	2317
Uniprot ID:	FLNB_HUMAN
Specificity:	This antibody detects endogenous levels of FLNB at Human
Immunogen:	Synthesized peptide derived from human FLNB

Post Translational Modifications	ISGylation prevents ability to interact with the upstream activators of the JNK cascade and inhibits IFNA-induced JNK signaling. Ubiquitination by a SCF-like complex containing ASB2 isoform 1 leads to proteasomal degradation which promotes muscle differentiation.
Function	Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.
Protein Name	Filamin-B Fln-B Abp-278 Abp-280 Homolog Actin-Binding-Like Protein Beta-Filamin Filamin Homolog 1 Fh1 Filamin-3 Thyroid Autoantigen Truncated Actin-Binding Protein Truncated Abp
Database Links	Reactome: R-HSA-1169408
Cellular Localisation	Isoform 1: Cytoplasm Cell Cortex Cytoplasm Cytoskeleton Stress Fiber Myofibril Sarcomere Z Line In Differentiating Myotubes Isoform 1 Isoform 2 And Isoform 3 Are Localized Diffusely Throughout The Cytoplasm With Regions Of Enrichment At The Longitudinal Actin Stress Fiber In Differentiated Tubes Isoform 1 Is Also Detected Within The Z-Lines Isoform 2: Cytoplasm Isoform 3: Cytoplasm Isoform 6: Cytoplasm Polarized At The Periphery Of Myotubes
Alternative Antibody Names	Anti-Filamin-B antibody Anti-Fln-B antibody Anti-Abp-278 antibody Anti-Abp-280 Homolog antibody Anti-Actin-Binding-Like Protein antibody Anti-Beta-Filamin antibody Anti-Filamin Homolog 1 antibody Anti-Fh1 antibody Anti-Filamin-3 antibody Anti-Thyroid Autoantigen antibody Anti-Truncated Actin-Binding Protein antibody Anti-Truncated Abp antibody Anti-FLNB antibody Anti-FLN1L antibody Anti-FLN3 antibody Anti-TABP antibody Anti-TAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FLNB antibody (STJA0008150)