Anti-FNBP1 antibody (1-210) (STJ112327) STJ112327 上海玉博生物科技有限公司

Anti-FNBP1 antibody (1-210) (STJ112327)

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产品名称：Anti-FNBP1 antibody (1-210) (STJ112327)
产品型号：STJ112327
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FNBP1 antibody (1-210) (STJ112327)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FNBP1 (1-210) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:1000-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FNBP1
Gene ID:	23048
Uniprot ID:	FNBP1_HUMAN
Immunogen Region:	1-210
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human FNBP1 (NP_055848.1).
Immunogen Sequence:	MSWGTELWDQFDNLEKHTQW GIDILEKYIKFVKERTEIEL SYAKQLRNLSKKYQPKKNSK EEEEYKYTSCKAFISNLNEM NDYAGQHEVISENMASQIIV DLARYVQELKQERKSNFHDG RKAQQHIETCWKQLESSKRR FERDCKEADRAQQYFEKMDA DINVTKADVEKARQQAQIRH QMAEDSKADYSSILQKFNHE QHEYYHTHIP

Tissue Specificity	Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
Function	May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.
Protein Name	Formin-Binding Protein 1 Formin-Binding Protein 17 Hfbp17
Database Links	Reactome: R-HSA-8856828 Reactome: R-HSA-9013148 Reactome: R-HSA-9013406 Reactome: R-HSA-9013409 Reactome: R-HSA-9696270
Cellular Localisation	Cytoplasm Cytoskeleton Cell Cortex Lysosome Cytoplasmic Vesicle Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Membrane Clathrin-Coated Pit Enriched In Cortical Regions Coincident With F-Actin Also Localizes To Endocytic Vesicles And Lysosomes
Alternative Antibody Names	Anti-Formin-Binding Protein 1 antibody Anti-Formin-Binding Protein 17 antibody Anti-Hfbp17 antibody Anti-FNBP1 antibody Anti-FBP17 antibody Anti-KIAA0554 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FNBP1 antibody (1-210) (STJ112327)