Anti-FNIP2 antibody (STJA0004850) STJA0004850 上海玉博生物科技有限公司

Anti-FNIP2 antibody (STJA0004850)

如果您对该产品感兴趣的话，可以
产品名称：Anti-FNIP2 antibody (STJA0004850)
产品型号：STJA0004850
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FNIP2 antibody (STJA0004850)

产品描述

Host:	Rabbit
Applications:	WB/ELISA
Reactivity:	Human
Note:	FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Folliculin-Interacting Protein 2 is suitable for use in Western Blot and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification:	Antigen affinity purification
Concentration:	1.14 mg/mL
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for long term, and avoid freeze-thaw cycles.

Gene Symbol:	FNIP2
Gene ID:	57600
Uniprot ID:	FNIP2_HUMAN
Immunogen:	Synthetic peptide of human FNIP2

Tissue Specificity	Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenta and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in renal cell carcinoma than in normal kidney tissue. Higher levels detected in oncocytoma tumors than in normal kidney. Higher levels detected in renal cell carcinoma tumors than in normal kidney tissue.
Post Translational Modifications	Phosphorylated by AMPK.
Function	Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3. Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling. In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3. Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3. Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy. In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90. Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions.
Protein Name	Folliculin-Interacting Protein 2 Fnip1-Like Protein O6-Methylguanine-Induced Apoptosis 1 Protein
Database Links	Reactome: R-HSA-9639288
Cellular Localisation	Lysosome Membrane Cytoplasm Colocalizes With Flcn In The Cytoplasm
Alternative Antibody Names	Anti-Folliculin-Interacting Protein 2 antibody Anti-Fnip1-Like Protein antibody Anti-O6-Methylguanine-Induced Apoptosis 1 Protein antibody Anti-FNIP2 antibody Anti-FNIPL antibody Anti-KIAA1450 antibody Anti-MAPO1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-FNIP2 antibody (STJA0004850)