Anti-FOLR1 antibody (1-100) [S4857RM] (STJ11104857) STJ11104857 上海玉博生物科技有限公司

Anti-FOLR1 antibody (1-100) [S4857RM] (STJ11104857)

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产品名称：Anti-FOLR1 antibody (1-100) [S4857RM] (STJ11104857)
产品型号：STJ11104857
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FOLR1 antibody (1-100) [S4857RM] (STJ11104857)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit monoclonal antibody anti-Folate Receptor Alpha (1-100) is suitable for use in Western Blot research applications.

Clonality:	Monoclonal
Clone ID:	S4857RM
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FOLR1
Gene ID:	2348
Uniprot ID:	FOLR1_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Folate Binding Protein (FBP) /FOLR1 (NP_000793.1).
Immunogen Sequence:	MAQRMTTQLLLLLVWVAVVG EAQTRIAWARTELLNVCMNA KHHKEKPGPEDKLHEQCRPW RKNACCSTNTSQEAHKDVSY LYRFNWNHCGEMAPACKRHF

Tissue Specificity	Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
Post Translational Modifications	The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.
Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.
Protein Name	Folate Receptor Alpha Fr-Alpha Adult Folate-Binding Protein Fbp Folate Receptor 1 Folate Receptor - Adult Kb Cells Fbp Ovarian Tumor-Associated Antigen Mov18
Database Links	Reactome: R-HSA-204005 Reactome: R-HSA-5694530 Reactome: R-HSA-6807878
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor Apical Cell Membrane Basolateral Cell Membrane Gpi-Like-Anchor Secreted Cytoplasmic Vesicle Clathrin-Coated Vesicle Endosome Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane
Alternative Antibody Names	Anti-Folate Receptor Alpha antibody Anti-Fr-Alpha antibody Anti-Adult Folate-Binding Protein antibody Anti-Fbp antibody Anti-Folate Receptor 1 antibody Anti-Folate Receptor - Adult antibody Anti-Kb Cells Fbp antibody Anti-Ovarian Tumor-Associated Antigen Mov18 antibody Anti-FOLR1 antibody Anti-FOLR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FOLR1 antibody (1-100) [S4857RM] (STJ11104857)