Anti-FOSB antibody (1-100) (STJ118036) STJ118036 上海玉博生物科技有限公司

Anti-FOSB antibody (1-100) (STJ118036)

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产品名称：Anti-FOSB antibody (1-100) (STJ118036)
产品型号：STJ118036
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FOSB antibody (1-100) (STJ118036)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FOSB (1-100) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FOSB
Gene ID:	2354
Uniprot ID:	FOSB_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOSB (NP_006723.2).
Immunogen Sequence:	MFQAFPGDYDSGSRCSSSPS AESQYLSSVDSFGSPPTAAA SQECAGLGEMPGSFVPTVTA ITTSQDLQWLVQPTLISSMA QSQGQPLASQPPVVDPYDMP

Tissue Specificity	Isoform 11: Expressed in the nucleus accumbens of the striatum (at protein level).
Post Translational Modifications	Phosphorylated. Isoform 11: Phosphorylated at Ser-27 by CSNK2A1.phosphorylation increases protein stability and transactivation potential.
Function	Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGAGCTCA-3' and enhancing their transcriptional activity. As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin. Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway. Exhibits transactivation activity in vitro. Involved in the display of nurturing behavior towards newborns. May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy. Implicated in behavioral responses related to morphine reward and spatial memory. Isoform 11: Exhibits lower transactivation activity than isoform 1 in vitro. The heterodimer with JUN does not display any transcriptional activity, and may thereby act as an transcriptional inhibitor. May be involved in the regulation of neurogenesis in the hippocampus. May play a role in synaptic modifications in nucleus accumbens medium spiny neurons and thereby play a role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction. Seems to be more stably expressed with a half-life of ~9.5 hours in cell culture as compared to 1.5 hours half-life of isoform 1.
Protein Name	Protein Fosb Fosb Proto-Oncogene - Ap-1 Transcription Factor Subunit G0/G1 Switch Regulatory Protein 3 Transcription Factor Ap-1 Subunit Fosb
Database Links	Reactome: R-HSA-9018519 Reactome: R-HSA-9031628
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Protein Fosb antibody Anti-Fosb Proto-Oncogene - Ap-1 Transcription Factor Subunit antibody Anti-G0/G1 Switch Regulatory Protein 3 antibody Anti-Transcription Factor Ap-1 Subunit Fosb antibody Anti-FOSB antibody Anti-G0S3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FOSB antibody (1-100) (STJ118036)