Anti-FOXA1 antibody (263-472) (STJ117473) STJ117473 上海玉博生物科技有限公司

Anti-FOXA1 antibody (263-472) (STJ117473)

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产品名称：Anti-FOXA1 antibody (263-472) (STJ117473)
产品型号：STJ117473
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FOXA1 antibody (263-472) (STJ117473)

产品描述

Host:	Rabbit
Applications:	WB/IHC
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-FOXA1 (263-472) is suitable for use in Western Blot and Immunohistochemistry research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FOXA1
Gene ID:	3169
Uniprot ID:	FOXA1_HUMAN
Immunogen Region:	263-472
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 263-472 of human FOXA1 (NP_004487.2).
Immunogen Sequence:	QKRFKCEKQPGAGGGGGSGS GGSGAKGGPESRKDPSGASN PSADSPLHRGVHGKTGQLEG APAPGPAASPQTLDHSGATA TGGASELKTPASSTAPPISS GPGALASVPASHPAHGLAPH ESQLHLKGDPHYSFNHPFSI NNLMSSSEQQHKLDFKAYEQ ALQYSPYGSTLPASLPLGSA SVTTRSPIEPSALEPAYYQG VYSRPVLNTS

Tissue Specificity	Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
Function	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-ACAATTAGTTGTAGCTTCT-3'. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate.FOXA1 and FOXA2 seem to have at least in part redundant roles. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription.required for ESR1 binding to the NKX2-1 promoter in breast cancer cells.binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
Protein Name	Hepatocyte Nuclear Factor 3-Alpha Hnf-3-Alpha Hnf-3a Forkhead Box Protein A1 Transcription Factor 3a Tcf-3a
Database Links	Reactome: R-HSA-9018519 Reactome: R-HSA-9796292
Cellular Localisation	Nucleus
Alternative Antibody Names	Anti-Hepatocyte Nuclear Factor 3-Alpha antibody Anti-Hnf-3-Alpha antibody Anti-Hnf-3a antibody Anti-Forkhead Box Protein A1 antibody Anti-Transcription Factor 3a antibody Anti-Tcf-3a antibody Anti-FOXA1 antibody Anti-HNF3A antibody Anti-TCF3A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FOXA1 antibody (263-472) (STJ117473)