Anti-FOXO4 antibody (164-213 aa) (STJ93130) STJ93130 上海玉博生物科技有限公司

Anti-FOXO4 antibody (164-213 aa) (STJ93130)

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产品名称：Anti-FOXO4 antibody (164-213 aa) (STJ93130)
产品型号：STJ93130
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FOXO4 antibody (164-213 aa) (STJ93130)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Forkhead box protein O4 (164-213 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FOXO4
Gene ID:	4303
Uniprot ID:	FOXO4_HUMAN
Immunogen Region:	164-213 aa
Specificity:	FoxO4 Polyclonal Antibody detects endogenous levels of FoxO4 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human AFX at the amino acid range 164-213

Post Translational Modifications	Acetylation by CREBBP/CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity. Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization. May be phosphorylated at multiple sites by NLK. Monoubiquitinated.monoubiquitination is induced by oxidative stress and reduced by deacetylase inhibitors.results in its relocalization to the nucleus and its increased transcriptional activity. Deubiquitinated by USP7.deubiquitination is induced by oxidative stress.enhances its interaction with USP7 and consequently, deubiquitination.increases its translocation to the cytoplasm and inhibits its transcriptional activity. Hydrogene-peroxide-induced ubiquitination and USP7-mediated deubiquitination have no major effect on its protein stability.
Function	Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Protein Name	Forkhead Box Protein O4 Fork Head Domain Transcription Factor Afx1
Database Links	Reactome: R-HSA-198693 Reactome: R-HSA-5674400 Reactome: R-HSA-5689880 Reactome: R-HSA-9614399 Reactome: R-HSA-9614657 Reactome: R-HSA-9615017 Reactome: R-HSA-9617629 Reactome: R-HSA-9617828 Reactome: R-HSA-9733709
Cellular Localisation	Cytoplasm Nucleus When Phosphorylated Translocated From Nucleus To Cytoplasm Dephosphorylation Triggers Nuclear Translocation Monoubiquitination Increases Nuclear Localization When Deubiquitinated
Alternative Antibody Names	Anti-Forkhead Box Protein O4 antibody Anti-Fork Head Domain Transcription Factor Afx1 antibody Anti-FOXO4 antibody Anti-AFX antibody Anti-AFX1 antibody Anti-MLLT7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FOXO4 antibody (164-213 aa) (STJ93130)