Anti-FOXP3 antibody [7H9-D6-A10] (STJ99099) STJ99099 上海玉博生物科技有限公司

Anti-FOXP3 antibody [7H9-D6-A10] (STJ99099)

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产品名称：Anti-FOXP3 antibody [7H9-D6-A10] (STJ99099)
产品型号：STJ99099
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-FOXP3 antibody [7H9-D6-A10] (STJ99099)

产品描述

Host:	Mouse
Applications:	WB/ICC
Reactivity:	Transfected
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Mouse monoclonal antibody anti-Forkhead box protein P3 is suitable for use in Western Blot and Immunocytochemistry research applications.

Clonality:	Monoclonal
Clone ID:	7H9-D6-A10
Conjugation:	Unconjugated
Isotype:	IgG1
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:300 ICC 1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FOXP3
Gene ID:	50943
Uniprot ID:	FOXP3_HUMAN
Specificity:	Transfected Only
Immunogen:	Purified recombinant human FOXP3 protein fragments expressed in E.coli.

Function	Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7. Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development. Inhibits the transcriptional activator activity of RORA. Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4.
Protein Name	Forkhead Box Protein P3 Scurfin Cleaved Into - Forkhead Box Protein P3 - C-Terminally Processed - Forkhead Box Protein P3 41 Kda Form
Database Links	Reactome: R-HSA-8877330 Reactome: R-HSA-8939256
Cellular Localisation	Nucleus Cytoplasm Predominantly Expressed In The Cytoplasm In Activated Conventional T-Cells Whereas Predominantly Expressed In The Nucleus In Regulatory T-Cells (Treg) The 41 Kda Form Derived By Proteolytic Processing Is Found Exclusively In The Chromatin Fraction Of Activated Treg Cells
Alternative Antibody Names	Anti-Forkhead Box Protein P3 antibody Anti-Scurfin Cleaved Into - Forkhead Box Protein P3 - C-Terminally Processed - Forkhead Box Protein P3 41 Kda Form antibody Anti-FOXP3 antibody Anti-IPEX antibody Anti-JM2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-FOXP3 antibody [7H9-D6-A10] (STJ99099)