Anti-INPP4A antibody (1-250) (STJ110004) STJ110004 上海玉博生物科技有限公司

Anti-INPP4A antibody (1-250) (STJ110004)

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产品名称：Anti-INPP4A antibody (1-250) (STJ110004)
产品型号：STJ110004
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-INPP4A antibody (1-250) (STJ110004)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-INPP4A (1-250) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	INPP4A
Gene ID:	3631
Uniprot ID:	INP4A_HUMAN
Immunogen Region:	1-250
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human INPP4A (NP_004018.1).
Immunogen Sequence:	MTAREHSPRHGARARAMQRA STIDVAADMLGLSLAGNIQD PDEPILEFSLACSELHTPSL DRKPNSFVAVSVTTPPQAFW TKHAQTEIIEGTNNPIFLSS IAFFQDSLINQMTQVKLSVY DVKDRSQGTMYLLGSGTFIV KDLLQDRHHRLHLTLRSAES DRVGNITVIGWQMEEKSDQR PPVTRSVDTVNGRMVLPVDE SLTEALGIRSKYASLRKDTL LKSVFGGAICRMYRFPTTD

Tissue Specificity	Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
Function	Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current. Isoform 4: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.
Protein Name	Inositol Polyphosphate-4-Phosphatase Type I A Inositol Polyphosphate 4-Phosphatase Type I Type I Inositol 3 -4-Bisphosphate 4-Phosphatase
Database Links	Reactome: R-HSA-1660499 Reactome: R-HSA-1660516 Reactome: R-HSA-1855183
Cellular Localisation	Early Endosome Membrane Recycling Endosome Membrane Cell Membrane Nucleus Cytoplasm Postsynaptic Density Translocates To The Plasma Membrane Upon Egf Stimulation Shuttles Between The Cytoplasm And The Nucleus Depending On The Cell Cycle Stage With Highest Amounts Detected In The Nucleus During The G0/G1phase
Alternative Antibody Names	Anti-Inositol Polyphosphate-4-Phosphatase Type I A antibody Anti-Inositol Polyphosphate 4-Phosphatase Type I antibody Anti-Type I Inositol 3 -4-Bisphosphate 4-Phosphatase antibody Anti-INPP4A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-INPP4A antibody (1-250) (STJ110004)