Anti-LOX antibody (300-417) (STJ110011) STJ110011 上海玉博生物科技有限公司

Anti-LOX antibody (300-417) (STJ110011)

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产品名称：Anti-LOX antibody (300-417) (STJ110011)
产品型号：STJ110011
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-LOX antibody (300-417) (STJ110011)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-LOX (300-417) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:100-1:500 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	LOX
Gene ID:	4015
Uniprot ID:	LYOX_HUMAN
Immunogen Region:	300-417
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 300-417 of human LOX (NP_002308.2).
Immunogen Sequence:	EFSHYDLLDANTQRRVAEGH KASFCLEDTSCDYGYHRRFA CTAHTQGLSPGCYDTYGADI DCQWIDITDVKPGNYILKVS VNPSYLVPESDYTNNVVRCD I

Tissue Specificity	Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Post Translational Modifications	The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytically cleaved by BMP1 which removes the propeptide. Also proteolytically cleaved by ADAMTS2 and ADAMTS14, but not by ADAMTS3, at an additional cleavage site downstream of the BMP1 cleavage site. The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin. Cleavage by BMP1 to remove the propeptide does not increase enzymatic activity but increases binding to collagen. Cleavage by ADAMTS2 produces a form with reduced collagen-binding activity. Sulfated at Tyr-187 and also at either Tyr-183 or Tyr-184 which enhances binding to collagen.
Function	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
Protein Name	Protein-Lysine 6-Oxidase Lysyl Oxidase Cleaved Into - Protein-Lysine 6-Oxidase - Long Form - Protein-Lysine 6-Oxidase - Short Form
Database Links	Reactome: R-HSA-1566948 Reactome: R-HSA-2243919
Cellular Localisation	Secreted Extracellular Space
Alternative Antibody Names	Anti-Protein-Lysine 6-Oxidase antibody Anti-Lysyl Oxidase Cleaved Into - Protein-Lysine 6-Oxidase - Long Form - Protein-Lysine 6-Oxidase - Short Form antibody Anti-LOX antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-LOX antibody (300-417) (STJ110011)