Anti-NBN antibody (650-750) (STJ110016) STJ110016 上海玉博生物科技有限公司

Anti-NBN antibody (650-750) (STJ110016)

如果您对该产品感兴趣的话，可以
产品名称：Anti-NBN antibody (650-750) (STJ110016)
产品型号：STJ110016
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-NBN antibody (650-750) (STJ110016)

产品描述

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-NBN (650-750) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NBN
Gene ID:	4683
Uniprot ID:	NBN_HUMAN
Immunogen Region:	650-750
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 650-750 of human NBS1/NBS1/NBN (NP_002476.2).
Immunogen Sequence:	LPKKLLLTEFRSLVIKNSTS RNPSGINDDYGQLKNFKKFK KVTYPGAGKLPHIIGGSDLI AHHARKNTELEEWLRQEMEV QNQHAKEESLADDLFRYNPY L

Tissue Specificity	Ubiquitous. Expressed at high levels in testis.
Post Translational Modifications	Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and telomere maintenance.
Function	Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
Protein Name	Nibrin Cell Cycle Regulatory Protein P95 Nijmegen Breakage Syndrome Protein 1
Database Links	Reactome: R-HSA-2559586 Reactome: R-HSA-5685938 Reactome: R-HSA-5685939 Reactome: R-HSA-5685942 Reactome: R-HSA-5693548 Reactome: R-HSA-5693554 Reactome: R-HSA-5693565 Reactome: R-HSA-5693568 Reactome: R-HSA-5693571 Reactome: R-HSA-5693579 Reactome: R-HSA-5693607 Reactome: R-HSA-5693616 Reactome: R-HSA-6804756 Reactome: R-HSA-69473 Reactome: R-HSA-912446 Reactome: R-HSA-9701192 Reactome: R-HSA-9704331 Reactome: R-HSA-9704646 Reactome: R-HSA-9709570 Reactome: R-HSA-9709603
Cellular Localisation	Nucleus Pml Body Chromosome Telomere Localizes To Discrete Nuclear Foci After Treatment With Genotoxic Agents Acetylation Of 'Lys-5' Of Histone H2ax (H2axk5ac) Promotes Nbn/Nbs1 Assembly At The Sites Of Dna Damage
Alternative Antibody Names	Anti-Nibrin antibody Anti-Cell Cycle Regulatory Protein P95 antibody Anti-Nijmegen Breakage Syndrome Protein 1 antibody Anti-NBN antibody Anti-NBS antibody Anti-NBS1 antibody Anti-P95 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!

温馨提示：为规避购买风险，建议您在购买前务必确认供应商资质与产品质量。
免责申明：以上内容为注册会员自行发布，若信息的真实性、合法性存在争议，平台将会监督协助处理，欢迎举报

产品目录

产品资料

Anti-NBN antibody (650-750) (STJ110016)