Anti-SYT4 antibody (38-190) (STJ110048) STJ110048 上海玉博生物科技有限公司

Anti-SYT4 antibody (38-190) (STJ110048)

简单介绍

Anti-SYT4 antibody (38-190) (STJ110048)

产品描述

Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-SYT4 (38-190) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:1000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SYT4
Gene ID:	6860
Uniprot ID:	SYT4_HUMAN
Immunogen Region:	38-190
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 38-190 of human SYT4 (NP_065834.1).
Immunogen Sequence:	CQRKSSKSNKTPPYKFVHVL KGVDIYPENLNSKKKFGADD KNEVKNKPAVPKNSLHLDLE KRDLNGNFPKTNLKPGSPSD LENATPKLFLEGEKESVSPE SLKSSTSLTSEEKQEKLGTL FFSLEYNFERKAFVVNIKEA RGLPAMDEQSMTS

Tissue Specificity	Expressed in melanocytes. Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus.
Post Translational Modifications	Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility.
Function	Synaptotagmin family member which does not bind Ca(2+). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses. Plays a role in dendrite formation by melanocytes.
Protein Name	Synaptotagmin-4 Synaptotagmin Iv Sytiv
Cellular Localisation	Cytoplasmic Vesicle Secretory Vesicle Neuronal Dense Core Vesicle Membrane Single-Pass Membrane Protein
Alternative Antibody Names	Anti-Synaptotagmin-4 antibody Anti-Synaptotagmin Iv antibody Anti-Sytiv antibody Anti-SYT4 antibody Anti-KIAA1342 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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