Anti-TOP1 antibody (1-100) (STJ110052) STJ110052 上海玉博生物科技有限公司

Anti-TOP1 antibody (1-100) (STJ110052)

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产品名称：Anti-TOP1 antibody (1-100) (STJ110052)
产品型号：STJ110052
产品展商：ST john's laboratory
产品文档：无相关文档

简单介绍

Anti-TOP1 antibody (1-100) (STJ110052)

产品描述

Host:	Rabbit
Applications:	WB
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-TOP1 (1-100) is suitable for use in Western Blot research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	TOP1
Gene ID:	7150
Uniprot ID:	TOP1_HUMAN
Immunogen Region:	1-100
Immunogen:	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human DNA topoisomerase I (DNA topoisomerase I (TOP1) ) (NP_003277.1).
Immunogen Sequence:	MSGDHLHNDSQIEADFRLND SHKHKDKHKDREHRHKEHKK EKDREKSKHSNSEHKDSEKK HKEKEKTKHKDGSSEKHKDK HKDRDKEKRKEEKVRASGDA

Tissue Specificity	Endothelial cells.
Post Translational Modifications	Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment. Phosphorylation at Ser-506 by CK2 increases binding to supercoiled DNA and sensitivity to camptothecin.
Function	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the BMAL1 promoter.
Protein Name	Dna Topoisomerase 1 Dna Topoisomerase I
Database Links	Reactome: R-HSA-4615885
Cellular Localisation	Nucleus Nucleolus Nucleoplasm Diffuse Nuclear Localization With Some Enrichment In Nucleoli On Cpt Treatment Cleared From Nucleoli Into Nucleoplasm Sumoylated Forms Found In Both Nucleoplasm And Nucleoli
Alternative Antibody Names	Anti-Dna Topoisomerase 1 antibody Anti-Dna Topoisomerase I antibody Anti-TOP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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Anti-TOP1 antibody (1-100) (STJ110052)